{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:59:14Z","timestamp":1789469954337,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["T5\u2010AN\u201007"],"award-info":[{"award-number":["T5\u2010AN\u201007"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Food allergy (FA) is one of the most common chronic conditions in children. Diagnostic delays and errors in FA are relevant problems in clinical practice. Non\u2010invasive and accessible tools for FA diagnosis are highly required. We aimed to develop an easy\u2010to\u2010use clinical score to facilitate the diagnostic approach for pediatric FA (i.e. the NAPFA score).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects with suspected FA aged 0\u201314\u2009years were prospectively evaluated at a tertiary center for pediatric allergy, gastroenterology, and nutrition.<\/jats:p>\n                    <jats:p>Upon completing the diagnostic workup, the subjects were diagnosed with FA based on the oral food challenge result, or with other conditions. Bootstrapped multivariable logistic regression was employed to construct two models that estimate the probability of having FA, one (M1) without the results of the allergy screening tests, while the other (M2) including them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six hundred and twenty\u2010seven pediatric subjects were included in the study. The median (interquartile interval) age at symptom onset was 8 (3;27) months. M1 employed the following predictors: sex, age at symptoms onset, cesarean delivery, occurrence of atopic dermatitis before FA onset, first degree family members with allergy, symptoms occurrence after ingestion of specific food, and skin, gastrointestinal, respiratory, and systemic symptoms. M2 replaced the occurrence of symptoms after ingestion of specific food with the results of allergy tests. The c\u2010statistic was 0.915 (95% bootstrapped CI: 0.895\u20130.937) for M1 and 0.977 (95% CI: 0.969\u20130.992) for M2. Both models demonstrated good internal calibration and a favorable decision analysis curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The NAPFA score could be an easy\u2010to\u2010use tool holding the potential to streamline the FA diagnostic process in pediatric age, reducing unnecessary testing, and improving patient outcomes in a variety of healthcare settings. Its external validation will possibly enable a standardized approach for identifying children with FA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70071","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T07:18:07Z","timestamp":1743491887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Naples pediatric food allergy (NAPFA) score: A multivariable model for the prediction of food allergy in children"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-3999","authenticated-orcid":false,"given":"Laura","family":"Carucci","sequence":"first","affiliation":[{"name":"Department of Translational Medical Science University of Naples \u201cFederico II\u201d  Naples Italy"},{"name":"ImmunoNutritionLab, CEINGE Advanced Biotechnologies Research Center University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Biancardi","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Nocerino","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science University of Naples \u201cFederico II\u201d  Naples Italy"},{"name":"ImmunoNutritionLab, CEINGE Advanced Biotechnologies Research Center University of Naples \u201cFederico II\u201d  Naples Italy"},{"name":"Department of Biomedicine and Prevention University of Rome \u201cTor Vergata\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Ciliberti","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Caldaria","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1495-9306","authenticated-orcid":false,"given":"Giorgio","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum\u2010University of Bologna  Bologna Italy"},{"name":"Department of Primary Health Care, Internal Medicine Unit Addressed to Frailty and Aging \u201cS. Maria Delle Croci\u201d Hospital, AUSL Romagna  Ravenna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Palmese","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum\u2010University of Bologna  Bologna Italy"},{"name":"Department of Primary Health Care, Internal Medicine Unit Addressed to Frailty and Aging \u201cS. Maria Delle Croci\u201d Hospital, AUSL Romagna  Ravenna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1484-0217","authenticated-orcid":false,"given":"Francesco","family":"Calabr\u00f2","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Applications \u201cRenato Caccioppoli\u201d University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Berni Canani","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science University of Naples \u201cFederico II\u201d  Naples Italy"},{"name":"ImmunoNutritionLab, CEINGE Advanced Biotechnologies Research Center University of Naples \u201cFederico II\u201d  Naples Italy"},{"name":"Task Force on Microbiome Studies University of Naples \u201cFederico II\u201d  Naples Italy"},{"name":"European Laboratory for the Investigation of Food\u2010Induced Diseases University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.10.011"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2024.100246"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13882"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2333794X19891298"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12423"},{"key":"e_1_2_16_8_1","first-page":"564","volume-title":"Le risposte attuali del Servizio Sanitario Nazionale. 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