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Therefore, this study examined the prospective association between psychopathology in childhood and current atopic and non\u2010atopic asthma in adolescents, considering sex and puberty\u2010related characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study includes 3584 participants (1790 females, 1794 males) from two German birth cohort studies, GINIplus and LISA. Psychopathological symptoms at age 10 (\n                      <jats:italic>M<\/jats:italic>\n                      \u2009=\u200910.06, SD\u2009=\u2009.22) were assessed by parent\u2010reported Strengths and Difficulties Questionnaire (SDQ) and current asthma at age 15 (\n                      <jats:italic>M<\/jats:italic>\n                      \u2009=\u200915.07, SD\u2009=\u2009.30) was defined as a positive parent\u2010reported medical diagnosis, wheezing, and\/or medical treatment against asthma (at least two criteria). Atopic asthma was characterized as current asthma and a positive specific immunoglobulin E (IgE) test (\u22650.35\u2009kU\/L), non\u2010atopic asthma as current asthma without sensitization. Data were analyzed by logistic regression and multinomial regression models, controlling for potential covariates and confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Psychopathological symptoms at age 10 were associated with asthma at age 15 (odds ratio (OR)\u2009=\u20091.69, 95% confidence interval (CI)\u2009=\u20091.04\u20132.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.035). When examining the endotypes, this effect was replicated only for non\u2010atopic asthma at age 15 (relative risk ratio (RRR)\u2009=\u20092.92, 95% CI\u2009=\u20091.13\u20137.60,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.028), but not for atopic asthma (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.381). Regarding the SDQ subscales, an association between peer problems at age 10 and atopic asthma at age 15 was revealed (RRR\u2009=\u20092.00, 95% CI 1.01\u20133.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.048). Furthermore, significant interaction effects of puberty onset with psychopathological symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.020), and particularly with peer problems (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.029), were found on atopic asthma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings highlight the importance of early recognition and treatment of psychopathological symptoms to prevent and reduce development, persistence and exacerbation of asthma endotypes, and point to the necessity for further research into hormonal mechanisms linking psychopathology with atopy.<\/jats:p>\n                  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