{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:26Z","timestamp":1772160866907,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U01EH000990"],"award-info":[{"award-number":["U01EH000990"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U01EH001130"],"award-info":[{"award-number":["U01EH001130"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U01EH000991"],"award-info":[{"award-number":["U01EH000991"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000204","name":"U.S. Department of Housing and Urban Development","doi-asserted-by":"publisher","award":["1\u2010PHI\u201001062"],"award-info":[{"award-number":["1\u2010PHI\u201001062"]}],"id":[{"id":"10.13039\/100000204","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Household mold is a major problem in communities which face natural disasters such as hurricanes or flooding, and in homes with other sources of significant water intrusion; a biomarker for exposure to indoor mold could support public health investigations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed serum from 132 children with asthma living in government\u2010subsidized housing for six microbial volatile organic compounds (2\u2010ethyl\u20101\u2010hexanol, 2\u2010heptanone, 2\u2010hexanone, 3\u2010methylfuran, 3\u2010octanone, and geosmin) using GC\u2013MS. Fewer than 10% of the samples for three compounds (2\u2010ethyl\u20101\u2010hexanol, 2\u2010heptanone, and 2\u2010hexanone) were quantified below the limit of detection. Associations between mold\/water damage variables and microbial volatile organic compounds (mVOCs) were assessed via regression analyses, adjusting for urinary cotinine and self\u2010reported home characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Children with household mold (assessed by occupant report of visual mold, mold odor, or water damage) had 32% higher serum concentrations of 2\u2010hexanone than those living in homes without reported mold or water damage. We investigated indoor tobacco use via urinary cotinine analysis of a \u201cfirst morning void spot sample\u201d (FMV) and found that children with higher urinary cotinine had significantly higher serum 2\u2010ethyl\u20101\u2010hexanol. We found that children in homes where residents reported tobacco smoking indoors had significantly higher serum 2\u2010ethyl\u20101\u2010hexanol compared with those without reported household smoke exposure. Tobacco smoke, indoor painting, gas stoves, and carpets were not confounders in the relationship between mVOCs and mold\/water damage variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>2\u2010hexanone, along with an index variable which included all detectable mVOCs in our panel, are promising biomarkers of recent mold exposure that could be used in concert with other detection methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70173","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T06:35:29Z","timestamp":1755758129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel biomarkers to assess mold exposure among children with asthma"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-6294","authenticated-orcid":false,"given":"Lalith K.","family":"Silva","sequence":"first","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health U.S. Centers for Disease Control and Prevention (CDC)  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cody A.","family":"Newman","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health U.S. Centers for Disease Control and Prevention (CDC)  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-5761","authenticated-orcid":false,"given":"Idris J.","family":"Wazeerud\u2010Din","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health U.S. Centers for Disease Control and Prevention (CDC)  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9158-8594","authenticated-orcid":false,"given":"Mitchell M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health U.S. Centers for Disease Control and Prevention (CDC)  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health U.S. Centers for Disease Control and Prevention (CDC)  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanzhe","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health U.S. Centers for Disease Control and Prevention (CDC)  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health U.S. Centers for Disease Control and Prevention (CDC)  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Ashley","sequence":"additional","affiliation":[{"name":"US Department of Housing and Urban Development  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Adamkiewicz","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiina","family":"Reponen","sequence":"additional","affiliation":[{"name":"Department of Environmental and Public Health Sciences University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Werthmann","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-6278","authenticated-orcid":false,"given":"Felicia A.","family":"Rabito","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin C.","family":"Blount","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences, National Center for Environmental Health U.S. Centers for Disease Control and Prevention (CDC)  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginger L.","family":"Chew","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Science and Practice National Center for Environmental Health, CDC  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-2-202"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16142499"},{"key":"e_1_2_13_4_1","unstructured":"De Jesus MirandaVR.The role of fungal metabolic by\u2010products in indoor air chemistry: analytical considerations for the evaluation of poor indoor environments.2001. 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