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Cost\u2010effectiveness analyses can facilitate a model of value\u2010based care; in this review, we aim to highlight key health\u2010economic analyses in anaphylaxis. Health economic evaluations suggest that screening approaches to prevent anaphylaxis have low value. Prolonged observation of asymptomatic patients with resolved anaphylaxis rarely makes health\u2010economic sense, and the most cost\u2010effective community epinephrine device is the one the patient can access and afford. With an expanding array of safe and effective active treatment options to decrease anaphylaxis risk and burden, management should be individualized, taking into account patient values and preferences.<\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                      <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/pai70176-gra-0001-m.png\">\n                        <jats:alt-text>image<\/jats:alt-text>\n                      <\/jats:graphic>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1111\/pai.70176","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:35:17Z","timestamp":1756290917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cost\u2010effective care in anaphylaxis prevention and management"],"prefix":"10.1111","volume":"36","author":[{"given":"Jason","family":"Sanders","sequence":"first","affiliation":[{"name":"Dartmouth Hitchcock Medical Center Department of Pediatrics  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Boldt","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brinda Prasanna","family":"Kumar","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center Section of Allergy and Immunology  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1800-2577","authenticated-orcid":false,"given":"Marcus","family":"Shaker","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center Section of Allergy and Immunology  Lebanon New Hampshire USA"},{"name":"Department of Medicine and Pediatrics Geisel School of Medicine at Dartmouth  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2025.01.021"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.06.031"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.05.049"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.09.036"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4240"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/clt.2.70071"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30029-8"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.18041"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.11.002"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2500\/jfa.2024.6.230018"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2022.09.007"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.01.004"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.07.017"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.2376"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.04.007"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.08.011"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.05.012"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2025.46.250015"},{"key":"e_1_2_12_20_1","unstructured":"US Department of Transportation.Departmental Guidance on Valuation of a Statistical Life in Economic Analysis. 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