{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:53:48Z","timestamp":1790834028990,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The literature includes scarce data on pediatric local anesthetics (LA) allergy and its diagnostic test results.<\/jats:p><\/jats:sec>Objective<\/jats:title>This study aimed to determine the prevalence of true LA allergy over 30\u2009years.<\/jats:p><\/jats:sec>Method<\/jats:title>We evaluated clinical data and test results of patients with suspected immediate\u2010type LA allergy.<\/jats:p><\/jats:sec>Results<\/jats:title>This study group consisted of 231 children with a median (interquartile\u2010range) age of 9.1\u2009years (6.5\u201312.9), with a male predominance (57.6%). The majority of reactions occurred during the dental procedures (84.8%). The most common presenting symptoms were mucocutaneous system reactions in 208 patients (90%). A total of 250 SPTs<\/jats:styled-content> were performed in all 231 patients with the following drugs: Articaine n<\/jats:italic>\u2009=\u200973 (29.2%), Lidocaine n<\/jats:italic>\u2009=\u200971 (28.4%), Prilocaine n<\/jats:italic>\u2009=\u200965 (26%), and Mepivacaine n<\/jats:italic>\u2009=\u200940 (16%). Local anesthetic allergy was confirmed by positive skin tests (1 SPT<\/jats:styled-content>, 9 IDT<\/jats:styled-content>) in 10 patients (4.3%), including 8 patients with one LA<\/jats:styled-content> and 2 patients with two LAs. In patients with true LA<\/jats:styled-content> allergy, the median age of the reaction was significantly lower (p<\/jats:italic>\u2009=\u2009.004), whereas the rate of anaphylaxis was found to be higher (p<\/jats:italic>\u2009<\u2009.001). Multivariate analysis suggested that a symptom of urticaria (OR<\/jats:styled-content>: 21.724 [95% CI<\/jats:styled-content>: 3.349\u2013140.934], p<\/jats:italic>\u2009=\u2009.001, VIF<\/jats:styled-content>\u2009=\u20091.074), a history of anaphylaxis (OR<\/jats:styled-content>: 40.690 [95% CI<\/jats:styled-content>: 5.877\u2013281.747], p<\/jats:italic>\u2009<\u2009.001, VIF<\/jats:styled-content>\u2009=\u20091.056), testing with articaine (OR<\/jats:styled-content>: 34.559 [95% CI<\/jats:styled-content>: 3.846\u2013310.507], p<\/jats:italic>\u2009=\u2009.002, VIF<\/jats:styled-content>\u2009=\u20091.010), and family history of atopy (OR<\/jats:styled-content>: 9.410 [95% CI<\/jats:styled-content>: 1.438\u201361.593], p<\/jats:italic>\u2009=\u2009.019, VIF<\/jats:styled-content>\u2009=\u20091.027) were potential risk factors for true LA<\/jats:styled-content> allergy, although these findings should be interpreted with caution due to the limited number of cases.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>True LA allergy was detected in 4.3% of patients, slightly higher than reported in the literature. This may be due to our center being a regional referral center and the study population including immediate\u2010type reactions. Despite the widespread use of LA, IgE\u2010mediated allergy is less common than expected but not rare.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.70178","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:11:55Z","timestamp":1755846715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Thirty years' experience with immediate\u2010type local anesthetic hypersensitivity reactions in children"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7841-4690","authenticated-orcid":false,"given":"Melike","family":"Ocak","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Bal \u00c7etinkaya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015feg\u00fcl","family":"Akarsu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"\u0130lg\u00fcn G\u00fcrel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"\u00dcnsal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Soyak Aytekin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-913X","authenticated-orcid":false,"given":"Umit Murat","family":"Sahiner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7402-6850","authenticated-orcid":false,"given":"Bulent Enis","family":"Sekerel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-251X","authenticated-orcid":false,"given":"Ozge","family":"Soyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Hacettepe University Ankara 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