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Systemic inflammation is thought to influence lung development and exercise\u2010induced bronchoconstriction (EIB), but its relationship to circulating inflammatory proteins in adolescents is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate associations between systemic inflammatory biomarkers and baseline lung function and post\u2010exercise airway responses in adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In 143 adolescents (13\u201315\u2009years) from a population\u2010based cohort, baseline spirometry, FOT, and baseline blood samples were obtained. Participants completed an exercise challenge to assess EIB via changes in forced expiratory volume in 1\u2009s (FEV\n                      <jats:sub>1<\/jats:sub>\n                      ), resistance at 5\u2009Hz (R\n                      <jats:sub>5<\/jats:sub>\n                      ), and reactance at 5\u2009Hz (X\n                      <jats:sub>5<\/jats:sub>\n                      ). Plasma protein levels were measured using the proximity extension assay technique (Olink Target Inflammation and Immune Response panels). Associations with lung function (FEV\n                      <jats:sub>1<\/jats:sub>\n                      % predicted, R5, and X5 z\u2010scores) and post\u2010exercise responses (\u2206FEV\n                      <jats:sub>1<\/jats:sub>\n                      , \u2206R5, \u2206X5) were analyzed using linear regression with false discovery rate correction. Interaction with atopy was also examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher plasma levels of C\u2010C motif chemokine 19 (CCL19) were significantly associated with lower FEV\n                      <jats:sub>1<\/jats:sub>\n                      % predicted and lower X\n                      <jats:sub>5<\/jats:sub>\n                      z\u2010scores at baseline, indicating reduced lung function and impaired small airway function. No proteins were associated with post\u2010exercise airway responses after correction. Five proteins showed significant interactions with atopy in relation to EIB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated CCL19 may reflect systemic inflammatory processes contributing to impaired lung function in early adolescence. The observed atopy\u2010related interactions suggest the need to consider atopy in studies of systemic inflammation and airway physiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70231","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:25:41Z","timestamp":1761294341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic inflammatory biomarkers in relation to lung function and exercise\u2010induced bronchoconstriction in adolescents"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3185-3316","authenticated-orcid":false,"given":"Karin","family":"Ersson","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Clinical Physiology Uppsala University  Uppsala Sweden"},{"name":"Department of Women's and Children's Health, Physiotherapy Uppsala University  Uppsala 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