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For over two decades, palivizumab was the only monoclonal antibody (mAb) available for prophylaxis, restricted to high\u2010risk groups due to cost and limited duration of protection. Recent advances in structural virology and antibody engineering have led to the emergence of long\u2010acting mAbs, notably nirsevimab and clesrovimab, which offer single\u2010dose seasonal protection and are now shifting RSV prevention strategies from high\u2010risk targeting to universal infant immunization. These antibodies act by locking the RSV fusion (F) protein in its pre\u2010fusion conformation, thereby preventing viral entry, with nirsevimab targeting site \u00d8 and clesrovimab targeting site IV. Real\u2010world implementation has demonstrated remarkable reductions in RSV hospitalizations, aligning with clinical trial results, while large\u2010scale safety data support their favorable tolerance. 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