{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:22:48Z","timestamp":1772990568161,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The frequency of false negatives in exercise provocation tests (EPTs) when evaluating exercise\u2010induced allergic reactions on desensitization (EIARD) remains unclear. This study aimed to determine the frequency of allergic symptom induction after a negative EPT result in patients at risk of EIARD and to identify its associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed 109 patients aged 5\u201318\u2009years who underwent EPTs between February 2012 and March 2023 to assess EIARD after wheat oral immunotherapy (OIT). EPT was performed in all cases after rush OIT and in high\u2010risk cases after slow OIT. Patients with a negative\/indeterminate EPT result were monitored for 1\u2009year. Individuals who developed allergic reactions during exercise after wheat ingestion were categorized as \u201cEvent+\u201d and were regarded as having false\u2010negative EPT results. Patients without events were categorized as \u201cEvent\u2212\u201d. Candidate factors between the Event+ and Event\u2212 groups were compared using nonparametric statistical tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 53 patients with negative\/indeterminate EPT results, 14 (26.4%) experienced allergic symptoms during follow\u2010up (Event+ group). Higher \u03c95\u2010gliadin\u2010specific IgE levels at the time of EPT were significantly associated with Event+. No other factors (i.e., age, sex, allergy severity, or exercise intensity) showed any association. All Event+ cases occurred outdoors, suggesting a possible influence of environmental factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>False negatives occurred in 26.4% of pediatric wheat\u2010desensitized patients with EPTs. Our findings highlight the need to periodically monitor EIARD after negative EPT results. Future studies should explore methods to improve the accuracy of EPTs and identify predictive markers of EIARD risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70274","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:33:53Z","timestamp":1767422033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors associated with false negative exercise provocation tests following exercise\u2010induced allergic reactions in children desensitized to wheat"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5323-0718","authenticated-orcid":false,"given":"Motohiro","family":"Mukai","sequence":"first","affiliation":[{"name":"Department of Allergy, Allergy and Immunology Center Aichi Children's Health and Medical Center  Obu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-1823","authenticated-orcid":false,"given":"Teruaki","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Allergy, Allergy and Immunology Center Aichi Children's Health and Medical Center  Obu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8962-851X","authenticated-orcid":false,"given":"Katsumasa","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Allergy, Allergy and Immunology Center Aichi Children's Health and Medical Center  Obu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-3575","authenticated-orcid":false,"given":"Yoshihiro","family":"Takasato","sequence":"additional","affiliation":[{"name":"Department of Allergy, Allergy and Immunology Center Aichi Children's Health and Medical Center  Obu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-2704","authenticated-orcid":false,"given":"Shiro","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Allergy, Allergy and Immunology Center Aichi Children's Health and Medical Center  Obu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-7973","authenticated-orcid":false,"given":"Komei","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Allergy, Allergy and Immunology Center Aichi Children's Health and Medical Center  Obu Japan"},{"name":"Comprehensive Pediatric Medicine Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Consumer Affairs Agency Government of Japan.Fiscal Year Survey and Research Project on Food Labeling Related to Food Allergies Report.2024https:\/\/www.caa.go.jp\/policies\/policy\/food_labeling\/food_sanitation\/allergy\/assets\/food_labeling_cms204_241031_1.pdf. 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