{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:25:51Z","timestamp":1787995551714,"version":"build-2784847793"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low total serum IgE has emerged as a potential marker of inborn errors of immunity (IEI), but no predictive tool exists to stratify risk in pediatric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, 677 children with IgE &lt;2.5\u2009IU\/mL were analyzed. We handled missing data with mean\u2010value imputation, applied SMOTE to address class imbalance, and conducted feature selection via ANOVA F\u2010test and SelectKBest. Ten machine\u2010learning models were trained and tuned using nested five\u2010fold cross\u2010validation (5\u2009\u00d7\u20095 repeats). Primary evaluation metrics included sensitivity, specificity, and area under the receiver operating characteristic curve (AUROC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Random Forest classifier achieved the highest performance (AUROC 0.86; sensitivity 0.81; specificity 0.75). Key predictors included lymphocyte, platelet, and neutrophil counts, mean platelet volume, and C\u2010reactive protein.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data\u2010driven framework accurately identifies children at risk for IEI using routine laboratory parameters. Prospective external validation and integration into clinical workflows are warranted to facilitate early diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70283","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:34:32Z","timestamp":1768991672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Machine learning\u2010based prediction of inborn errors of immunity in patients with low IgE levels"],"prefix":"10.1111","volume":"37","author":[{"given":"Ali","family":"\u015eahin","sequence":"first","affiliation":[{"name":"Department of Emergency Service Dr. Vefa Tan\u0131r Ilg\u0131n State Hospital  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3488-0283","authenticated-orcid":false,"given":"Gamze","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Hacettepe University, School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Unsal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Immunology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Cagdas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Immunology Hacettepe University Faculty of Medicine  Ankara Turkey"},{"name":"Faculty of Medicine, Ihsan Dogramaci Childrens Hospital Hacettepe University  Ankara Turkey"},{"name":"Department of Pediatric Immunology, Institute of Child Health Hacettepe University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2022.07.013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63188-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2024.110403"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-022-01289-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.70962\/jhi.20250003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-019-0681-4"},{"key":"e_1_2_9_9_1","volume-title":"Urologic Oncology: Seminars and Original Investigations","author":"Alt\u0131nta\u015f E","year":"2024"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2024.110235"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-024-01806-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109759"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"S7","article-title":"Who's your data? Primary immune deficiency differential diagnosis prediction via machine learning and data mining of the USIDNET registry","volume":"42","author":"Barrera J","year":"2022","journal-title":"J Clin Immunol"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.70283","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:25:11Z","timestamp":1772972711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.70283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/pai.70283"],"URL":"https:\/\/doi.org\/10.1111\/pai.70283","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.70283\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70283\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70283\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70283\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70283\/v1\/review2","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70283"}}