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During the past 2 decades, IgE\u2010mediated wheat allergy in children has been frequently observed all over the World, especially in Asia. Wheat allergy usually presents in infants between 6 and 12\u2009months of age. Common clinical manifestations are skin rashes (maculopapular rash, urticaria and angioedema). Atopic dermatitis is a less common presenting manifestation in wheat allergy compared to those with egg and cow's milk allergy. Anaphylaxis occurs in up to 50% of wheat allergy in children. Wheat\u2010dependent, exercise\u2010induced anaphylaxis is more common among older children, teenagers and adults. Skin prick testing with water\u2010soluble extract of wheat gave low diagnostic sensitivity. This is because major wheat allergens are alcohol\u2010soluble proteins. Specific IgE to components of wheat such as \u03c9\u20105 gliadin could increase diagnostic accuracy. The use of these component\u2010resolved wheat allergens both in singleplex and multiplex tests is available but the accuracy of these tests remains to be verified. Wheat avoidance is difficult to carry out since wheat is used for cooking in a wide variety of daily diets. Oral immunotherapy to wheat has been extensively investigated over the past 15\u2009years among children with varying degrees of wheat sensitivities. Most of these children achieved some degree of desensitization to wheat but only a few attained sustained unresponsiveness. To date, it is unclear how long wheat oral immunotherapy should be maintained. Recently, an outbreak in Japan on allergy to soap containing hydrolyzed\u2010wheat suggested that the route of sensitization of wheat was through skin. Discontinuation of marketing of this soap led to cessation of the epidemic. Such knowledge warrants further investigation in children so that a prevention measure for wheat allergy among high\u2010risk infants can be designed.<\/jats:p>","DOI":"10.1111\/pai.70288","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:26:38Z","timestamp":1770809198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Wheat allergy, a new and emerging threat of food allergy for\u00a0children"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5103-2916","authenticated-orcid":false,"given":"Pakit","family":"Vichyanond","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010Ichi","family":"Nagakura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National 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