{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:28:39Z","timestamp":1777984119769,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In mild atopic dermatitis (AD), evaluating disease activity during maintenance therapy is challenging due to subtle clinical signs. Serum squamous cell carcinoma antigen 2 (SCCA2) has been proposed as a sensitive biomarker, but its utility in assessing disease status specifically in mild AD remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the utility of serum SCCA2 in children with mild AD receiving maintenance therapy, focusing on its relationship with patient\u2010reported outcomes. Serum thymus and activation\u2010regulated chemokine (TARC), an established marker, was analyzed as a comparator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010nine pediatric patients with mild AD were enrolled. Clinical severity was assessed by the Eczema Area and Severity Index (EASI; physician\u2010rated) and the Patient\u2010Oriented Eczema Measure (POEM; patient\u2010reported). Baseline serum SCCA2 and TARC were measured. Associations were first examined using Spearman's rank correlation. Temporal associations between baseline SCCA2 and POEM at Days 3 and 7 were further evaluated using linear mixed\u2010effects models, and complementary bootstrap resampling and Steiger's Z test were applied for correlation comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although all patients were classified as mild by EASI, POEM scores ranged widely, indicating discordance between physician\u2010 and patient\u2010assessed severity. SCCA2, but not TARC, was significantly correlated with POEM scores at baseline. The correlation between baseline SCCA2 and POEM was strongest on Day 3 and attenuated by Day 7. Linear mixed\u2010effects modeling confirmed a significant time\u2010dependent association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SCCA2 reflects patient\u2010experienced symptom burden more closely than physician\u2010assessed severity in mild AD. Its short\u2010term, time\u2010dependent association with POEM suggests potential utility for identifying early or imminent symptom burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70298","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T11:40:24Z","timestamp":1770032424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SCCA2 as a biomarker reflecting patient\u2010reported disease burden in children with mild atopic dermatitis under maintenance therapy"],"prefix":"10.1111","volume":"37","author":[{"given":"Yasuaki","family":"Yasuda","sequence":"first","affiliation":[{"name":"Allergy Center NHO Mie National Hospital  Tsu Japan"},{"name":"Department of Child Health and Development Mie University Graduate School of Medicine  Tsu 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