{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:50Z","timestamp":1787015990769,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D may play a role in early lung development, yet epidemiologic evidence on its association with later asthma risk is mixed. We aimed to investigate the associations of neonatal 25\u2010hydroxyvitamin D (25(OH)D) and vitamin D\u2010binding protein (DBP) and their corresponding genetic predictors with asthma risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a population\u2010based cohort study of a random sample of individuals born in Denmark during 1991\u20132005 from the iPSYCH2012 study. Neonatal concentrations of 25(OH)D and DBP were measured via dried blood spots, and asthma cases were identified through diagnoses or asthma prescriptions after age 5\u2009years. Cox regression was used to estimate hazard ratios (HRs) for asthma in relation to 25(OH)D, DBP, and polygenic scores (PGSs) for these traits and asthma to assess genetic liability to vitamin D status and asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 14,005 individuals, 2308 (16.5%) developed asthma over a maximum follow\u2010up of 25\u2009years. We found no association between neonatal 25(OH)D (HR\u2009=\u20091.04, 95% CI: 0.99\u20131.09 per SD increase) or DBP (HR\u2009=\u20091.01, 95% CI: 0.97\u20131.05) and asthma risk. Analyses using tertiles to assess potential non\u2010linear associations yielded similar null results. A higher asthma PGS was associated with increased asthma risk (HR\u2009=\u20091.42, 95% CI: 1.36\u20131.47 per SD increase), whereas PGSs for 25(OH)D (HR\u2009=\u20091.00, 95% CI: 0.96\u20131.05) and DBP (HR\u2009=\u20090.99, 95% CI: 0.95\u20131.04) were not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggests that neonatal vitamin D status is not associated with asthma risk. Similarly, genetic liability related to vitamin D status, as reflected in PGSs for 25(OH)D and DBP, is not associated with an increased risk of asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70299","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:58:22Z","timestamp":1770022702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal vitamin D status and asthma risk after age 5\u2009years: A Danish population\u2010based cohort study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4519-1536","authenticated-orcid":false,"given":"Xiaoqin","family":"Liu","sequence":"first","affiliation":[{"name":"NCRR\u2010The National Centre for Register\u2010Based Research, Department of Public Health Aarhus University  Aarhus 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Grundvad","family":"Boelt","sequence":"additional","affiliation":[{"name":"Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nis","family":"Borbye\u2010Lorenzen","sequence":"additional","affiliation":[{"name":"Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Melgaard","sequence":"additional","affiliation":[{"name":"Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten B\u00f8cker","family":"Pedersen","sequence":"additional","affiliation":[{"name":"NCRR\u2010The National Centre for Register\u2010Based Research, Department of Public Health Aarhus University  Aarhus 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