{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:30:34Z","timestamp":1792801834695,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006120","name":"Ministry of the Environment, Government of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Isoflavone (ISO) consumption during pregnancy may affect food allergy (FA) in offspring through estrogen\u2010like and other biological effects; however, this ISO\u2013FA association in mother\u2013child pairs remains elusive. Herein, the maternal ISO\u2013childhood FA association was investigated using the Japanese birth cohort data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The data from the Japan Environment and Children's Study, including 86,012 and 75,307 mother\u2013child pairs, with FA in children aged \u22641\u2009year and 1\u20133\u2009years, respectively, were analyzed. Maternal ISO consumption (total daidzein and genistein) was assessed using a food frequency questionnaire. Physician\u2010diagnosed FA data were obtained using questionnaires completed by caregivers. ISO consumption data was categorized into quartiles (Q1: reference), and the ISO\u2013FA association was assessed through multivariable logistic regression analysis after adjusting for maternal age, educational level, smoking status, pre\u2010pregnancy body mass index, history of allergies, blood folic acid concentration, total energy intake, and infant feeding method up to 4\u2009months of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, FA cases in children aged \u22641 and 1\u20133\u2009years were 6.6% and 12.1%, respectively. Maternal ISO consumption was negatively associated with FA in all children aged \u22641\u2009year (Q3, adjusted odds ratio [aOR]: 0.91, 95% confidence interval [CI]: 0.84\u20130.99; Q4, aOR: 0.86, 95% CI: 0.79\u20130.93) and in those aged 1\u20133\u2009years (Q3, aOR: 0.93, 95% CI: 0.88\u20130.99; Q4, aOR: 0.88, 95% CI: 0.83\u20130.95). Furthermore, in sex\u2010stratified analysis, a negative association was observed between maternal ISO consumption and FA in female children of all ages, whereas this inverse association was observed only in 1\u20133\u2010year\u2010old male children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, the findings show that maternal ISO consumption during pregnancy may reduce the risk of childhood FA, exhibiting sex\u2010difference effects on offspring development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70303","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:04:32Z","timestamp":1771481072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between maternal dietary isoflavone consumption during pregnancy and childhood food allergy in offspring: The Japan Environment and Children's study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7753-6186","authenticated-orcid":false,"given":"Gui","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Nutrition and Metabolic Medicine, Center for Preventive Medical Sciences Chiba University  Inageku, Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Hisada","sequence":"additional","affiliation":[{"name":"Department of Sustainable Health Science, Center for Preventive Medical Sciences Chiba University  Inageku, Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Sustainable Health Science, Center for Preventive Medical Sciences Chiba University  Inageku, Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rieko","family":"Takatani","sequence":"additional","affiliation":[{"name":"Faculty of Education Chiba University  Inageku, Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Environmental Preventive Medicine (Yamada Bee Company, Inc.), Center for Preventive Medical Sciences Chiba University  Inageku, Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Shimojo","sequence":"additional","affiliation":[{"name":"Allergy Center Chiba University Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Metabolic Medicine, Center for Preventive Medical Sciences Chiba University  Inageku, Chiba 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