{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:46:22Z","timestamp":1791229582875,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100024932","name":"Children\u2019s Health Foundation","doi-asserted-by":"publisher","award":["SFG\u201024\u2010TRA008"],"award-info":[{"award-number":["SFG\u201024\u2010TRA008"]}],"id":[{"id":"10.13039\/501100024932","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Unsubstantiated antibiotic allergy labels affect between 8% and 25% of the population worldwide. Current risk stratification tools, derived from adult data, are not validated for children. A simplified, multi\u2010patient protocol with minimal exclusion criteria is required to tackle the scale of this public health issue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with possible antibiotic allergy were recruited from the Children's Health Ireland (CHI) allergy waiting list. Exclusion criteria were a serum sickness like reaction (SSLR), severe cutaneous adverse reaction (SCARs), anaphylaxis, or non\u2010allergic symptoms. No prior allergy testing was performed. Dosing was direct single observed dosing in dedicated mass delabelling clinics, followed by a two\u2010day home antibiotic course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Consenting patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009162) were seen over 6 clinics with gradually increasing clinic sizes (Range 18 to 62, average 23). One patient only was excluded based on the severity of their index event. Average age was 7\u2009years,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200990\/162 (55.6%) were female. Most were avoiding amoxicillin,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009137\/162 (84.6%). Negative challenge rates were similar to previous studies,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009150\/162 (92.6%), 3 had immediate reactions and 9 delayed (all non\u2010severe). Patients retrospectively underwent risk stratification according to the 2024 EAACI position paper, high risk\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938\/162 (23.5%), intermediate risk\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200974\/162 (45.7%) and low risk\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950\/162 (30.9%). Those deemed high risk were no more likely to have a positive challenge than those deemed low\/intermediate risk (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092\/38, 5.3% vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910\/124, 8.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.56).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Antibiotic allergy delabelling in pediatrics is low risk and can be done safely in high patient load without prior allergy testing. Current risk stratification tools are not suitable for pediatric\u2010specific models of care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70324","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:41:39Z","timestamp":1773380499000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Direct single dose mass delabelling of antibiotic allergy in pediatrics"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2812-6502","authenticated-orcid":false,"given":"Sheena","family":"Coyne","sequence":"first","affiliation":[{"name":"Children's Health Ireland (CHI)  Dublin Ireland"},{"name":"Royal College of Surgeons Ireland (RCSI)  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aideen","family":"Byrne","sequence":"additional","affiliation":[{"name":"Children's Health Ireland (CHI)  Dublin 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