{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:13:00Z","timestamp":1788307980890,"version":"build-2803163510"},"reference-count":102,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atopic dermatitis (AD), asthma, food allergy, and respiratory allergy are common childhood conditions with significant disease burden. Current understanding implicates the skin\u2010barrier and the dual\u2010allergen hypotheses in the pathophysiology of these allergic conditions. This systematic review and meta\u2010analysis aimed to investigate the role of genes associated with primary skin barrier dysfunction in childhood atopic conditions. We conducted a comprehensive search across Embase, MEDLINE, Emcare, CINAHL, and Cochrane Central databases, yielding 6018 abstracts and 941 full\u2010text articles, of which 60 met the inclusion criteria. Quality assessment was performed using the Q\u2010GENIE tool. The full protocol is available on the PROSPERO database (registration ID CRD42022355771). Our analysis confirms a role for the filaggrin (FLG) gene, with meta\u2010analysis revealing associations between FLG loss\u2010of\u2010function (LOF) mutations and AD (OR 2.426, 95% CI 1.890\u20133.114) in cohort studies and (OR 4.44, 95% CI 2.42\u20138.12) in case\u2013control studies, asthma (OR 1.90, 95% CI 1.33\u20132.71), and food allergy (OR 1.79, 95% CI 1.11\u20132.88) in cohort studies. No statistically significant associations were found between FLG mutations and food allergy in case\u2013control studies, or respiratory allergies. Included studies with insufficient clinical homogeneity for meta\u2010analysis were presented as narrative synthesis, with studies looking at genetic associations with\n                    <jats:italic>FLG<\/jats:italic>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200928), FLG\u20102 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091) and IL\u201018 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091). The findings underscore the critical role of\n                    <jats:italic>FLG<\/jats:italic>\n                    mutations in childhood allergic conditions, particularly AD and asthma. However, we did not identify quantitative evidence for a clinically significant role for other skin barrier\u2010related genes in relation to childhood allergy. Limitations include the exclusion of non\u2010English\u2010language studies and potential omissions of genes not represented in the Gene Ontology Skin Barrier database. Future research could explore personalized medicine according to\n                    <jats:italic>FLG<\/jats:italic>\n                    genotype to mitigate the effects of environmental exposures and reduce the burden of atopic diseases in children.\n                  <\/jats:p>","DOI":"10.1111\/pai.70326","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:40:52Z","timestamp":1776994852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skin barrier\u2010related genes in childhood atopic dermatitis, asthma, and allergy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"37","author":[{"given":"I.","family":"Husain","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine Brighton and Sussex Medical School  Brighton UK"},{"name":"Royal Alexandra Children's Hospital University Hospitals Sussex NHS Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Royal Free London NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Holden","sequence":"additional","affiliation":[{"name":"Royal Alexandra Children's Hospital University Hospitals Sussex NHS Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Jervis","sequence":"additional","affiliation":[{"name":"Royal Alexandra Children's Hospital University Hospitals Sussex NHS Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Barnard","sequence":"additional","affiliation":[{"name":"Royal Alexandra Children's Hospital University Hospitals Sussex NHS Trust  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Medical Education Brighton and Sussex Medical School  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Felton","sequence":"additional","affiliation":[{"name":"Croydon Health Services NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bremner","sequence":"additional","affiliation":[{"name":"Division of Methodologies, Faculty of Nursing, Midwifery and Palliative Care King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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