{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:26:59Z","timestamp":1791538019397,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21tm0124005"],"award-info":[{"award-number":["JP21tm0124005"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21tm0424601"],"award-info":[{"award-number":["JP21tm0424601"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24gn0110088"],"award-info":[{"award-number":["JP24gn0110088"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2114"],"award-info":[{"award-number":["JPMJSP2114"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25KJ0575"],"award-info":[{"award-number":["25KJ0575"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) is a chronic inflammatory skin disease that primarily develops during childhood. Residential greenness has been reported to be associated with AD onset. However, findings are inconsistent and may not apply to Japanese settings because vegetation and residential environments vary regionally. Therefore, this study aimed to examine early\u2010life exposure to residential greenness and subsequent AD development in Japanese children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 14,932 children in the Tohoku Medical Megabank Project Birth and Three\u2010Generation Cohort Study. The exposure was residential greenness during the first 6\u2009months of life, quantified using the normalized difference vegetation index (NDVI) within 250\u2010, 500\u2010, and 1000\u2010m buffers around each birth postal code and categorized into tertiles (low [reference], moderate, high). The outcome was AD incidence between 6\u2009months and 5\u2009years of age, assessed via maternal reporting. Adjusted risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using modified Poisson regression. Analyses were stratified by urbanization levels, child's sex, and parental history of allergic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant protective association was observed among children in the high NDVI tertile within the 250\u2010m buffer (adjusted RR: 0.80, 95% CI: 0.67\u20130.95), whereas the moderate tertile was not significant (adjusted RR: 0.94, 95% CI: 0.83\u20131.06). A similar pattern was observed at 500\u2009m. Stratification showed similar associations across urbanization levels, which were stronger in boys and observed only among children without parental allergic history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early\u2010life exposure to residential greenness was associated with a decreased risk of AD in Japanese children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70338","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T03:20:12Z","timestamp":1775532012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Residential greenness and atopic dermatitis in Japanese children: Findings from the TMM BirThree cohort study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2209-919X","authenticated-orcid":false,"given":"Ami","family":"Uematsu","sequence":"first","affiliation":[{"name":"Graduate School of Medicine Tohoku University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6716-9095","authenticated-orcid":false,"given":"Hisashi","family":"Ohseto","sequence":"additional","affiliation":[{"name":"International Research Institute of Disaster Science Tohoku University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4871-8455","authenticated-orcid":false,"given":"Masatsugu","family":"Orui","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine Tohoku University  Sendai Miyagi Japan"},{"name":"International Research Institute of Disaster Science Tohoku University  Sendai Miyagi Japan"},{"name":"Tohoku Medical Megabank Organization Tohoku University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3617-2377","authenticated-orcid":false,"given":"Zheng","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Frontier Sciences for Advanced Environment, Graduate School of Environmental Studies Tohoku University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3708-9305","authenticated-orcid":false,"given":"Yuta","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Frontier Sciences for Advanced Environment, Graduate School of Environmental Studies Tohoku University  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-1388","authenticated-orcid":false,"given":"Geng","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate School 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