{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:06:55Z","timestamp":1791893215192,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence on the effectiveness of partially hydrolyzed formulas (pHF) as a nutritional intervention to prevent Allergic Manifestations (AM) is limited. Provided that not all pHF are the same in terms of allergenicity and immunogenicity, their role in reducing the risk of the Atopic March progression should be individually and longitudinally examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether the risk\u2010reduction effect of a specific pHF compared to a standard formula (SF) on Atopic Dermatitis (AD) within the first 6\u2009months of life observed in the Allergy Reduction Trial (A.R.T.) persists at the age of 5\u2009years and, if it applies to other AM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Parents\/legal guardians of participants within the multicenter double\u2010blinded randomized controlled clinical Allergy Reduction Trial (A.R.T.) who constituted the Intention\u2010to\u2010Treat population set (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009551) were invited at the age of 5\u2009years for an observational follow\u2010up, to answer an enriched validated questionnaire regarding doctor diagnosis of AM between 1 and 5\u2009years of age, including AD, Food Allergy (FA), Asthma, and Allergic Rhinitis (AR). The prevalence and cumulative incidence of outcomes were calculated and Relative Risks, 95% Confidence Interval (RR, 95% CI) were estimated by Poisson Generalized Estimating Equations adjusted for study center, sex, family history of AD, family history of AR, family history of Asthma, and mode of delivery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four hundred and fifty\u2010five subjects (83%) completed the 5\u2010year follow\u2010up (pHF: 131\/160, SF: 145\/171 and EBF: 179\/220). The RR from birth to 5\u2009years was significantly lower in the pHF group, for the development of any AM [32.7% vs. 51.7%, RR 0.73 (0.57\u20130.94),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02], AD [22.1% vs. 38.5%, RR 0.58 (0.41\u20130.83),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003] and, FA [10.5% vs. 20.4%, RR 0.53 (0.29\u20130.95),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.03] compared to the SF group. Infant feeding with the pHF resulted in 87% risk\u2010reduction of FA [1.5% vs. 12.4%, RR 0.13 (0.03\u20130.58),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.007] between the ages of 1\u20135\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In non\u2010exclusively breastfed infants at high\u2010risk for allergy, mixed\u2010feeding with a specific whey\u2010based pHF during the first 6\u2009months of life may reduce the risk of atopic dermatitis and food allergy from birth up to the age of 5\u2009years. However, further A.R.T. follow\u2010ups and other longitudinal studies with larger sample size are needed to provide additional evidence for the long\u2010term effectiveness of pHF in allergy prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70354","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:05:35Z","timestamp":1779203135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nutritional intervention with a partially hydrolyzed formula during the first 6\u2009months of life may reduce the risk of food allergy and atopic dermatitis up to the age of 5\u2009years"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8796-8334","authenticated-orcid":false,"given":"Mikaela","family":"Sekkidou","sequence":"first","affiliation":[{"name":"Asthma and Allergy Center  Limassol Cyprus"},{"name":"Department of Basic and Clinical Sciences University of Nicosia Medical School  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Karglani","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University  Athens Greece"},{"name":"European Centre for Obesity Harokopio University  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouzha","family":"Pancheva","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Faculty of Public Health \u201cProf. Dr. Paraskev Stoyanov\u201d Medical University \u2013 Varna  Varna Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paris","family":"Kantaras","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simoneta","family":"Popova","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Faculty of Public Health \u201cProf. Dr. Paraskev Stoyanov\u201d Medical University \u2013 Varna  Varna Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desislava","family":"Zhelyazkova","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Faculty of Public Health \u201cProf. Dr. Paraskev Stoyanov\u201d Medical University \u2013 Varna  Varna Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-9285","authenticated-orcid":false,"given":"Panayiotis K.","family":"Yiallouros","sequence":"additional","affiliation":[{"name":"Medical School University of Cyprus  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Philippou","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, School of Life and Health Sciences University of Nicosia  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Daniil","sequence":"additional","affiliation":[{"name":"Neonatal Department National and Kapodistrian University of Athens, Aretaieio Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Boutsikou","sequence":"additional","affiliation":[{"name":"Neonatal Department National and Kapodistrian University of Athens, Aretaieio Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoi","family":"Iliodromiti","sequence":"additional","affiliation":[{"name":"Neonatal Department National and Kapodistrian University of Athens, Aretaieio Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Iacovidou","sequence":"additional","affiliation":[{"name":"Neonatal Department National and Kapodistrian University of Athens, Aretaieio Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliki","family":"Papaevangelou","sequence":"additional","affiliation":[{"name":"Third Department of Pediatrics, National and Kapodistrian University of Athens ATTIKON General University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannis","family":"Manios","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University  Athens Greece"},{"name":"Department of Life Sciences, School of Life and Health Sciences University of Nicosia  Nicosia Cyprus"},{"name":"Institute of Agri\u2010Food and Life Sciences Hellenic Mediterranean University Research Centre  Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linde","family":"van Lee","sequence":"additional","affiliation":[{"name":"FrieslandCampina  Amersfoort the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaos","family":"Nicolaou","sequence":"additional","affiliation":[{"name":"Asthma and Allergy Center  Limassol Cyprus"},{"name":"Department of Basic and Clinical Sciences University of Nicosia Medical School  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.02.019"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12341"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2021_507"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40136-022-00406-5"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.04.004"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312382"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103212"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1154211"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.0000000000000001"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13650"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414850"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(05)81415-5"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02029362"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.77.1.4"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2002.00725.x"},{"key":"e_1_2_14_17_1","first-page":"1","volume-title":"Effects of a Dietary and Environmental Prevention Programme on the Incidence of Allergic Symptoms in High Atopic Risk Infants: Three Years Follow\u2010Up","author":"Marini A","year":"1996"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.1.80"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3022"},{"key":"e_1_2_14_20_1","volume-title":"Infant Feeding Advice.","author":"ASCIA 2010"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.007"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2014.17.2.61"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-014-0022-4"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2017.7.2.102"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60926-X"},{"key":"e_1_2_14_26_1","unstructured":"SeahLW MunAKK LatiffAHA et\u00a0al.Guidelines for the Management of cow's Milk Protein Allergy in Children 2012.2012.http:\/\/www.allergymsai.org"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12398"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003664.pub6"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i974"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2020.03.004"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13496"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003897"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.11.002"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxab064"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.12102"},{"key":"e_1_2_14_36_1","volume-title":"Preventing Food Allergy in Higher Risk Infants: Guidance for Healthcare Professionals","author":"BSACI BFASG","year":"2018"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114063"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12992"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.144758"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2023.8063"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.863599"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14709"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15112622"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12415"},{"key":"e_1_2_14_45_1","doi-asserted-by":"crossref","unstructured":"PanchevaR NicolaouN SekkidouM et\u00a0al.Evaluating the Long\u2010Term Impact of a Partially Hydrolyzed Formula on Allergy Prevention in High\u2010Risk Infants: The Allergy Reduction Trial (ART) 5\u2010Year Follow\u2010Up Protocol.2025. doi:10.17504\/protocols.io.kxygx4bezl8j\/v1","DOI":"10.17504\/protocols.io.kxygx4bezl8j\/v1"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-017-0195-4"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2024.1434461"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0144.5648"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-024-01131-3"},{"key":"e_1_2_14_52_1","unstructured":"MALAYSIAN.ALLERGY PREVENTION (MAP) guidelines for healthcare professionals.https:\/\/allergymsai.org\/pdf\/guideline\u2010map.pdf"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.04.021"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.05.006"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw011"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12790"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2354"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.5414\/ALX02303E"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-023-00814-2"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-6-21"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.11.918"}],"updated-by":[{"DOI":"10.1111\/pai.70494","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000}}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.70354","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:42:19Z","timestamp":1791891739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.70354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/pai.70354"],"URL":"https:\/\/doi.org\/10.1111\/pai.70354","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.70354\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70354\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70354\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70354\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70354\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70354\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70354"}}