{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:06:35Z","timestamp":1791893195657,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2023.02362.BD"],"award-info":[{"award-number":["2023.02362.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/4750\/2025"],"award-info":[{"award-number":["UID\/4750\/2025"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0064\/2020"],"award-info":[{"award-number":["LA\/P\/0064\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2024.10106.CEECIND"],"award-info":[{"award-number":["2024.10106.CEECIND"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asthma and obesity frequently coexist in childhood, yet whether asthma predisposes to later adiposity remains underexplored, particularly using measures beyond body mass index (BMI). Considering this, we aimed to examine the association between asthma in early childhood and subsequent adiposity through adolescence, assessed using BMI and body fat percentage, and to evaluate sex\u2010specific effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included 4717 participants from the Portuguese population\u2010based Generation XXI birth cohort. Physician\u2010diagnosed asthma at age 4\u2009years was the exposure. Incident obesity and overweight\/obesity were assessed at ages 7\u2010, 10\u2010, and 13\u2010years using BMI and body fat percentage estimated by bioelectrical impedance analysis and classified according to age\u2010 and sex\u2010specific percentiles. Children who were already overweight or obese at age 4 were excluded from the respective analysis. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI), adjusting for confounders. Effect modification by sex was tested, and sex\u2010stratified analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Asthma was associated with a higher risk of incident obesity defined by body fat percentage in adjusted analyses (aHR\u2009=\u20091.91, 95% CI: 1.16\u20133.16), whereas associations with BMI\u2010defined obesity were not statistically significant. Sex\u2010stratified analyses showed that these associations were confined to girls, who had increased risk of obesity (aHR\u2009=\u20091.97, 95% CI: 1.19\u20133.26) and overweight\/obesity (aHR\u2009=\u20091.75, 95% CI: 1.02\u20133.01) defined by body fat percentage. No significant associations were observed among boys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Asthma in early childhood was associated with increased adiposity in adolescence assessed by body fat percentage, particularly among girls. These findings suggest that children with asthma may develop excess fat accumulation not fully captured by BMI and support the integration of body composition and metabolic risk assessment into pediatric asthma care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70360","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:25:46Z","timestamp":1778829946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early childhood asthma and adiposity until adolescence: A prospective birth cohort study using body fat percentage"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7932-9460","authenticated-orcid":false,"given":"M\u00f3nica","family":"Rodrigues","sequence":"first","affiliation":[{"name":"EPIUnit ITR \u2013 Instituto de Sa\u00fade P\u00fablica da Universidade do Porto (ISPUP) Universidade do Porto  Porto 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