{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:09:43Z","timestamp":1788844183231,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014434","name":"Narodowa Agencja Wymiany Akademickiej","doi-asserted-by":"publisher","award":["BPI\/PST\/2024\/1\/00128"],"award-info":[{"award-number":["BPI\/PST\/2024\/1\/00128"]}],"id":[{"id":"10.13039\/501100014434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a heterogeneous clinical course. Distinct phenotypes show differences in age at onset, severity, and allergic profile; however, evidence from Central and Eastern Europe remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An anonymous online questionnaire distributed via social media targeted parents of children &lt;18\u2009years of age with physician\u2010diagnosed AD. The data included demographics, environmental exposures, AD history, proxy Patient\u2010Oriented Eczema Measure (POEM) scores, comorbidities, and self\u2010reported sensitizations. Children were stratified by age (&lt;6 vs. \u22656\u2009years). Latent class analysis (LCA) was used to identify phenotypes in age groups using age of onset, current severity, recent exacerbations, viral skin infections, and sensitization type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 435 children were included in this analysis (mean age, 3.92\u2009years; 59.8% male). AD onset before 6\u2009months occurred in 67.1% of patients. In children &lt;6\u2009years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009359), three phenotypes were identified: \u201cearly\u2010onset, moderate\u2010severe with co\u2010sensitization\u201d (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009100, 27.9%), with highest frequency of food allergy; \u201cearly\u2010onset, mild with food sensitization\u201d (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009195, 54.3%), and \u201clater\u2010onset, mild with aeroallergen sensitization\u201d (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200964, 17.8%). In children \u22656\u2009years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200976), two phenotypes emerged: \u201cearly\u2010onset with co\u2010sensitization\u201d (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953, 69.7%), which displayed higher frequency of atopic comorbidities, and \u201clater\u2010onset with aeroallergen sensitization\u201d (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923, 30.3%). The classes showed clear separation based on selected features.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Distinct, clinically relevant AD phenotypes were identified in children, which were in line with phenotypes reported in previous longitudinal studies, although based on cross\u2010sectional data. These findings underscore AD heterogeneity and support the utility of pragmatic, region\u2010specific surveys for phenotype identification outside longitudinal cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70367","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:03:56Z","timestamp":1783137836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenotypes of atopic dermatitis in Polish children\u2014Latent class analysis of cross\u2010sectional questionnaire\u2010based study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4239-1164","authenticated-orcid":false,"given":"Karolina","family":"Dumycz","sequence":"first","affiliation":[{"name":"Department of Pediatric Pneumonology and Allergy Medical University of Warsaw  Warsaw Poland"},{"name":"Doctoral School Medical University of Warsaw  Warsaw 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