{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T06:22:04Z","timestamp":1794205324556,"version":"4.8.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asthma is a heterogeneous disease with variable treatment responses. miRNAs play a critical role in asthma pathogenesis and may serve as biomarkers for distinct asthma endotypes. We tried to identify possible molecular asthma clusters based on miRNA expression profiles in pediatric patients from the Childhood Asthma Management Program (CAMP) cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed miRNA profiling and k\u2010means clustering on 462 CAMP participants. Differential miRNA expression and pathway enrichment analyses were conducted to characterize cluster\u2010associated molecular features. Clinical characteristics and budesonide\u2010related changes in lung function were compared across clusters, including analyses stratified by peripheral blood eosinophil counts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three possible molecular clusters were identified, each with distinct miRNA expression patterns and enriched biological pathways. All clusters showed enrichment in IL\u20104\/IL\u201013 signaling and PIP3\/AKT pathways. Cluster 1 was characterized by Toll\u2010like receptor\u2010related signaling pathways, Cluster 2 by FOXO\u2010mediated transcription pathways, and Cluster 3 by pathways associated with SCF\u2010KIT signaling. Baseline demographic and clinical characteristics were largely similar across clusters. However, patterns of budesonide\u2010related lung function change differed. Clusters 1 and 3 showed more favorable lung function profiles after budesonide treatment than Cluster 2. In Cluster 1, eosinophilic participants had a higher proportion of moderate asthma, whereas those without eosinophilia were more often classified as having mild asthma. In Cluster 3, eosinophilic participants had greater baseline airway hyperresponsiveness and lower baseline FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC but showed greater improvement in FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC after budesonide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>miRNA profiling identified possible molecular asthma clusters with different clinical, physiologic, and treatment\u2010related patterns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70374","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:44:22Z","timestamp":1778733862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MicroRNA clustering in pediatric asthma reveals differential corticosteroid responsiveness"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9861-0530","authenticated-orcid":false,"given":"Minsuk","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Pediatric Respiratory Medicine, Department of Pediatrics University of California san Diego  La Jolla California USA"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4096-9257","authenticated-orcid":false,"given":"Upasna","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin","family":"Kho","sequence":"additional","affiliation":[{"name":"Computational Health Informatics Program Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshul","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Molecular Physiology and Biophysics Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Wang","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Piparia","sequence":"additional","affiliation":[{"name":"Division of Pediatric Respiratory Medicine, Department of Pediatrics University of California san Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott T.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Brigham and Women's Hospital  Boston Massachusetts 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