{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:09:42Z","timestamp":1788844182525,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cold\u2010induced urticaria (ColdU) is a rare chronic inducible urticaria that can cause systemic reactions, including cold\u2010induced anaphylaxis (ColdA), but pediatric data are limited. The aim of this study was to evaluate the clinical characteristics, comorbidities, management approaches, risk of anaphylaxis, and long\u2010term course of ColdU in a pediatric cohort, and to identify risk factors for ColdA, determinants of disease resolution, and predictors of persistence into adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter study included 203 pediatric patients with ColdU across 30 centers in T\u00fcrkiye. Clinical characteristics and management of patients were analyzed. Logistic regression was used to identify factors associated with ColdA and disease resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age at diagnosis was 14.3\u2009years, and the median age at onset was 10\u2009years; 56.1% of patients were female. ColdA occurred in 17.2%, with increased risk associated with male sex, autoimmune comorbidities, older age, and triggering by cold food\/beverage ingestion. Most patients (82.2%) received second\u2010generation H1\u2010antihistamines; omalizumab achieved &gt;90% symptom control in 12 refractory cases. Over a median 3.5\u2010year follow\u2010up, 30.5% achieved disease resolution (median duration: 18\u2009months). The history of anaphylaxis and comorbid atopy significantly reduced the likelihood of remission. Some patients showed adult persistence, without clear predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>ColdA may occur even without classic high\u2010risk features; pediatric ColdU management should be guided by individualized risk assessment, prioritizing clinical risk factors\u2014such as older age, high\u2010risk cold triggers, angioedema, and autoimmune comorbidities\u2014over isolated diagnostic parameters. In refractory cases, omalizumab is an effective and well\u2010tolerated option. Prior anaphylaxis and comorbid allergic disease predicted poorer remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70379","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T04:27:02Z","timestamp":1780288022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PECU: A multicenter study on pediatric patients with cold\u2010induced urticaria"],"prefix":"10.1111","volume":"37","author":[{"given":"Betul Gemici","family":"Karaaslan","sequence":"first","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Pediatric Immunology and Allergy Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"},{"name":"Cerrahpasa Faculty of Medicine, Pediatric Allergy and Immunology Research Laboratory Istanbul University\u2010Cerrahpasa  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-352X","authenticated-orcid":false,"given":"Ozgen","family":"Soyoz","sequence":"additional","affiliation":[{"name":"Izmir Faculty of Medicine, Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, Department of Pediatric Allergy and Immunology University of Health Sciences  Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-4117","authenticated-orcid":false,"given":"Figen Celebi","family":"Celik","sequence":"additional","affiliation":[{"name":"Izmir Faculty of Medicine, Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, Department of Pediatric Allergy and Immunology University of Health Sciences  Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-5985","authenticated-orcid":false,"given":"Humeyra","family":"Akbas","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine, Pediatric Immunology and Allergy Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakup","family":"Canitez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pediatric Allergy Bursa Uludag University  Bursa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Ilbilge Ertoy","family":"Karagol","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pediatric Immunology and Allergy Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beril Canan","family":"Aksoydan","sequence":"additional","affiliation":[{"name":"SBU Gulhane Training and Research Hospital Pediatric Immunology and Allergy  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yagmur Hazal Sadirvan","family":"Oguzkaya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pediatric Allergy Bursa Uludag University  Bursa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"Uslu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Pediatric Allergy and Immunology Istanbul Medeniyet University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semiha 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