{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:09:46Z","timestamp":1788844186245,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100013293","name":"Active and Assisted Living Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013293","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bronchodilator response (BDR) is a key clinical feature in childhood asthma, but its relation to asthma pathophysiology is not fully understood. This study examines the associations between BDR, disease control, and serum cytokines\/chemokines in children with moderate\u2010to\u2010severe asthma (MSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      BDR was assessed in 140 children (aged 6\u201317\u2009years, 41% females) from the SysPharmPediA cohort using the ERS\/ATS 2022 guidelines (\u0394FEV\n                      <jats:sub>1<\/jats:sub>\n                      &gt;10% predicted) and\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score (\u0394FEV\n                      <jats:sub>1<\/jats:sub>\n                      \u2010\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score &gt;0.78) post\u2010bronchodilator definitions. Risk of uncontrolled asthma in relation to BDR was estimated by a logistic regression model, adjusting for baseline lung function, age, sex, BMI\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score, ethnicity, country, season, GINA step, and smoking exposure. Thirty\u2010nine serum proteins were measured using Luminex Multiplex Assay; levels below the detection limit (LOD) were imputed as LOD\/\u221a2, and proteins with &gt;40% missing values across samples were excluded. Children with high and low BDR were compared for serum proteins by linear regression model, adjusting for covariates and applying false discovery rate correction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Children with high BDR (21%) had significantly higher odds of uncontrolled asthma (adjusted OR \u2248\u20093.22, 95% CIs: 1.07\u201311.3) and more frequent severe exacerbations in the past year compared with those with low BDR (70% vs. 46%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). High\u2010BDR children showed elevated serum levels of IL\u201013, IL\u20104, TNF\u2010\u03b1, IL\u20106, IL\u20107, IL\u20108, IL\u20101\u03b2, and MMP\u20101 (\n                      <jats:italic>q<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In children with MSA, a high BDR is independently associated with poorer asthma control and a distinct systemic inflammatory profile involving T2 and non\u2010T2 mediators. BDR may serve as a marker for asthma phenotyping.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/pai70392-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70392","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:14:41Z","timestamp":1780913681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bronchodilator response is linked with uncontrolled moderate\u2010to\u2010severe childhood asthma and elevated\n                    <scp>IL<\/scp>\n                    \u20104\u00a0and\n                    <scp>IL<\/scp>\n                    \u201013"],"prefix":"10.1111","volume":"37","author":[{"given":"Nariman K. A.","family":"Metwally","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute for Infection and Immunity, Inflammatory Diseases  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health, Personalized Medicine  Amsterdam The Netherlands"},{"name":"Department of Pediatric Pulmonology and Allergy Emma Children's Hospital, Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Department of Public and Occupational Health, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute for Infection and Immunity, Inflammatory Diseases  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health, Personalized Medicine  Amsterdam The Netherlands"},{"name":"Department of Pediatric Pulmonology and Allergy Emma Children's Hospital, Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4579-4081","authenticated-orcid":false,"given":"Susanne J. H.","family":"Vijverberg","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute for Infection and Immunity, Inflammatory Diseases  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health, Personalized Medicine  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne H.","family":"Neerincx","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara S.","family":"Dierdorp","sequence":"additional","affiliation":[{"name":"Amsterdam Institute for Infection and Immunity, Inflammatory Diseases  Amsterdam the Netherlands"},{"name":"Department of Experimental Immunology, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Dekker","sequence":"additional","affiliation":[{"name":"Amsterdam Institute for Infection and Immunity, Inflammatory Diseases  Amsterdam the Netherlands"},{"name":"Department of Experimental Immunology, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric G.","family":"Haarman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergy Emma Children's Hospital, Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Duitman","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute for Infection and Immunity, Inflammatory Diseases  Amsterdam the Netherlands"},{"name":"Department of Experimental Immunology, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Gorenjak","sequence":"additional","affiliation":[{"name":"Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine University of Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoaneta A.","family":"Toncheva","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO)  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-5823","authenticated-orcid":false,"given":"Susanne","family":"Harner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO)  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Brandstetter","sequence":"additional","affiliation":[{"name":"University Children's Hospital University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wolff","sequence":"additional","affiliation":[{"name":"University Children's Hospital University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Corcuera\u2010Elosegui","sequence":"additional","affiliation":[{"name":"Division of Pediatric Respiratory Medicine Donostia University Hospital  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyre","family":"L\u00f3pez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Division of Pediatric Respiratory Medicine Donostia University Hospital  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaia","family":"Sard\u00f3n\u2010Prado","sequence":"additional","affiliation":[{"name":"Division of Pediatric Respiratory Medicine Donostia University Hospital  San Sebasti\u00e1n Spain"},{"name":"Department of Pediatrics. Faculty of Medicine and Nursing University of the Basque Country (UPV\/EHU)  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0332-437X","authenticated-orcid":false,"given":"Maria","family":"Pino\u2010Yanes","sequence":"additional","affiliation":[{"name":"Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology, and Genetics Universidad de La Laguna (ULL)  La Laguna Tenerife Spain"},{"name":"CIBER de Enfermedades Respiratorias Instituto de Salud Carlos III  Madrid Spain"},{"name":"Instituto de Tecnolog\u00edas Biom\u00e9dicas (ITB) Universidad de La Laguna (ULL)  La Laguna Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uro\u0161","family":"Poto\u010dnik","sequence":"additional","affiliation":[{"name":"Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine University of Maribor  Maribor Slovenia"},{"name":"Faculty of Chemistry and Chemical Engineering University of Maribor  Maribor Slovenia"},{"name":"Department for Science and Research University Medical Centre Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0697-1871","authenticated-orcid":false,"given":"Michael","family":"Kabesch","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO)  Regensburg Germany"},{"name":"University Children's Hospital University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aletta D.","family":"Kraneveld","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science Utrecht University  Utrecht CG The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Lutter","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute for Infection and Immunity, Inflammatory Diseases  Amsterdam the Netherlands"},{"name":"Department of Experimental Immunology, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne W. J.","family":"Terheggen\u2010Lagro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Allergy Emma Children's Hospital, Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-7137","authenticated-orcid":false,"given":"Mahmoud I.","family":"Abdel\u2010Aziz","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute for Infection and Immunity, Inflammatory Diseases  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health, Personalized Medicine  Amsterdam The Netherlands"},{"name":"Department of Genetics, UMC Groningen University of Groningen  Groningen Netherlands"},{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke H.","family":"Maitland\u2010van der Zee","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Institute for Infection and Immunity, Inflammatory Diseases  Amsterdam the Netherlands"},{"name":"Amsterdam Public Health, Personalized Medicine  Amsterdam The Netherlands"},{"name":"Department of Pediatric Pulmonology and Allergy Emma Children's Hospital, Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Department of Genetics, UMC Groningen University of Groningen  Groningen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the SysPharmPediA Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30399-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2018.1403318"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0201-2022"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/arm91050031"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00000102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00222-2024"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14186397"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9339-22"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12101"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01633-2019"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2017.80.2.105"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24473"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.01.012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11060484"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60532-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01499-2021"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.12.017"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2025.04.017"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2022.106360"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.11.029"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.12-OA-0530"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.03.008"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2013.878845"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2023.107375"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.35460\/2546-1621.2019-0003"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-016-0138-8"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3283292207"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.851940"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2023.107327"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13985"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2013.11.006"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36130"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.02.033"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02871.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-28"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.01.021"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-015-0081-1"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.3.1404"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(97)00296-7"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0822OC"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652408785160907"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01079-w"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1621OC"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.08.010"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2106567"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26632"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.10.011"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.70392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:20:39Z","timestamp":1788841239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.70392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/pai.70392"],"URL":"https:\/\/doi.org\/10.1111\/pai.70392","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/PAI.70392\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70392\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70392\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70392\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/PAI.70392\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70392"}}