{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:57:10Z","timestamp":1791363430999,"version":"4.3.1"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The evolution of mite sensitization profiles from childhood to adulthood is associated with distinct clinical outcomes. Longitudinal sensitization trajectories have never been addressed across two generations over an extended time frame. Using molecular diagnosis, we aimed to investigate how the evolution of mite sensitization relates to the expression of rhinitis and asthma in adult versus pediatric patients over a 20\u2010year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Specific IgE (sIgE) to mite molecular allergens was determined using the MeDALL allergen chip (Der p 1, 2, 4, 5, 7, 10, 11, 14, 15, 37, 18, 21 and 23; Der f 1, Der f 2, Lep d 2, Blot t 5). Assessment was made in adult (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921), adolescent (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911), and pediatric patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919) with rhinitis and\/or asthma, in T1 (20\u2010years ago) and in T2 (current time).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After the 20\u2010year period, the adult cohort significantly decreased the number of sIgE responses to mite components\u2014T1: 7 [3\u20139] versus T2: 4 [2\u20136], median [IQR],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0040. A strong negative correlation was observed between age and the 20\u2010year variation of sensitization count (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.5305;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). In adults, the reduction in mite molecular IgE responses was associated with improvement in rhinitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0010) and asthma (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0020), reflecting disease progression patterns not observed in the pediatric cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first analysis to show that molecular mite sensitization declines with aging, and this reduction may relate to decreased asthma and rhinitis symptoms and severity. This age\u2010associated decline highlights the importance of careful clinical interpretation in older adults to avoid overtreatment and missed diagnoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70401","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:26:15Z","timestamp":1782102375000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Involution of\n                    <scp>IgE<\/scp>\n                    sensitization to house dust mite allergen molecules by age"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2762-9354","authenticated-orcid":false,"given":"Filipa Matos","family":"Semedo","sequence":"first","affiliation":[{"name":"Allergy and Immunology Department, S\u00e3o Bernardo Hospital Centro Hospitalar de Set\u00fabal E.P.E.  Set\u00fabal Portugal"},{"name":"Department of Immunology, Nova Medical School NOVA University Lisbon  Lisbon Portugal"},{"name":"RISE\u2013Health, Faculty of Health Sciences University of Beira Interior  Covilh\u00e3 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia","family":"Dorofeeva","sequence":"additional","affiliation":[{"name":"Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Immunology, Nova Medical School NOVA University Lisbon  Lisbon Portugal"},{"name":"Comprehensive Health Research Centre (CHRC), NOVA Medical School Nova University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Pires","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Department, S\u00e3o Bernardo Hospital Centro Hospitalar de Set\u00fabal E.P.E.  Set\u00fabal Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"In\u00e1cio","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Department, S\u00e3o Bernardo Hospital Centro Hospitalar de Set\u00fabal E.P.E.  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