{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:07:46Z","timestamp":1788840466093,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mislabeling children as drug\u2010allergic leads to suboptimal, costly, and potentially harmful treatments. Although drug provocation tests (DPTs) are the gold standard for excluding drug hypersensitivity, the impact of these interventions on caregivers' willingness to reuse delabeled drugs remains elusive. We evaluated DPT outcomes and post\u2010DPT drug use and caregiver attitudes in pediatric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed children who underwent DPTs for suspected drug allergy at a tertiary pediatric allergy center between January 2019 and June 2023. Demographic and clinical data were reviewed, and caregivers were contacted \u22656\u2009months after DPT to assess subsequent drug use and concerns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 254 DPTs were performed in 198 children (55.1% male; median age: 58\u2009months). Drug allergy was confirmed in 25.3% of patients (50\/198), corresponding to 22.0% of tests (56\/254). Among 162 negative DPTs with follow\u2010up, the suspected drug was reused in 56.8% of cases; 92.4% were tolerated while 7.6% resulted in mild reactions.<\/jats:p>\n                    <jats:p>\n                      Multivariable logistic regression identified predictors of drug reuse: paracetamol (aOR: 7.40; 95% CI: 1.73\u201331.63;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.007), concomitant allergic disease (aOR: 2.51; 95% CI: 1.12\u20135.64;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.026), self\u2010referral (aOR: 3.81; 95% CI: 1.12\u201312.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.032), and younger age (aOR per month: 0.99; 95% CI: 0.98\u20131.00;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.017). Anaphylaxis at index reaction was associated with reduced reuse likelihood (aOR: 0.21; 95% CI: 0.06\u20130.76;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite negative DPT results, almost half of caregivers did not reuse the suspected drug, mostly due to fear or miscommunication. These findings highlight the importance of post\u2010DPT education and structured follow\u2010up to optimize delabeling outcomes.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/pai70435-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70435","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:31:57Z","timestamp":1784698317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attitudes of caregivers of children labeled with drug allergy after delabeling by provocation tests"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-6810","authenticated-orcid":false,"given":"\u015eeyma","family":"Kaya A\u011farg\u00fcn","sequence":"first","affiliation":[{"name":"Department of Pediatrics Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-1881","authenticated-orcid":false,"given":"Besim Faz\u0131l","family":"A\u011farg\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9190-6849","authenticated-orcid":false,"given":"Ay\u015fe","family":"S\u00fcleyman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Immunology, Department of Pediatrics Istanbul Faculty of Medicine, Istanbul University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7584-5401","authenticated-orcid":false,"given":"Sophia","family":"Tsabouri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3200-5493","authenticated-orcid":false,"given":"Zeynep \u00dclker","family":"Alt\u0131nel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Immunology, Department of Pediatrics Istanbul Faculty of Medicine, Istanbul University  Istanbul 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