{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:07:59Z","timestamp":1789603679950,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n This study applied two\u2010sample Mendelian randomization (MR) to elucidate causal relationships between sleep\u2010related phenotypes and childhood asthma risk.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Instrumental variables for daytime napping, sleep disorders, chronotype, and fatigue were selected from European ancestry genome\u2010wide association studies. Causal estimates were primarily derived using inverse\u2010variance weighting (IVW), supplemented by sensitivity analyses including MR\u2010Egger and MR\u2010PRESSO. Instrument validity, heterogeneity, pleiotropy, and directionality were rigorously evaluated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n IVW results demonstrated that genetic susceptibility to daytime napping (OR\u2009=\u20091.76; 95% CI: 1.07\u20132.88;\n p<\/jats:italic>\n \u2009<\u2009.05), sleep disorders (OR\u2009=\u20091.35; 95% CI: 1.12\u20131.61;\n p<\/jats:italic>\n \u2009<\u2009.05), and frequent fatigue (OR\u2009=\u20092.94; 95% CI: 1.61\u20135.38;\n p<\/jats:italic>\n \u2009<\u2009.05) significantly increased asthma risk, whereas morning chronotype was protective (OR\u2009=\u20090.76; 95% CI: 0.61\u20130.98;\n p<\/jats:italic>\n \u2009=\u2009.015). Sensitivity analyses supported these findings, with no evidence of pleiotropy or reverse causation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These results suggest that sleep behaviors causally influence childhood asthma risk and may represent modifiable targets for prevention and management.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.70446","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:49:37Z","timestamp":1786949377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Causal association between sleep phenotypes and susceptibility to childhood asthma: A two\u2010sample Mendelian randomization study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1636-4653","authenticated-orcid":false,"given":"Li","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Pediatrics Second Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xingtai Medical College Xingtai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Second Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Second Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Second Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Second Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Global Initiative for Asthma (GINA).Global Strategy for Asthma Management and Prevention.2023."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00246"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.14.0170"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00186"},{"key":"e_1_2_11_6_1","first-page":"11","article-title":"Childhood respiratory conditions: asthma","volume":"513","author":"Benton LD","year":"2022","journal-title":"FP Essent"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000987"},{"issue":"7","key":"e_1_2_11_8_1","first-page":"703","article-title":"Biotherapies in severe childhood asthma","volume":"73","author":"Bouderbala Y","year":"2023","journal-title":"Rev Prat"},{"key":"e_1_2_11_9_1","article-title":"Prevalence of sleep disturbances in children with asthma: a systematic review and meta\u2010analysis","volume":"53","author":"Wang R","year":"2020","journal-title":"Sleep Med Rev"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25264"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"449","article-title":"Sleep and asthma in urban children with asthma and their families","volume":"37","author":"Koinis\u2010Mitchell D","year":"2012","journal-title":"J Pediatr Psychol"},{"issue":"8","key":"e_1_2_11_12_1","first-page":"839","article-title":"Sleep and quality of life in children with asthma","volume":"48","author":"Krouse HJ","year":"2011","journal-title":"J Asthma"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0190-z"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-011-1044-0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000339"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq151"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007081"},{"issue":"3","key":"e_1_2_11_21_1","first-page":"300","article-title":"Sleep and asthma in urban children: the role of asthma severity, caregiver and child anxiety, and family stressors","volume":"37","author":"Koinis\u2010Mitchell D","year":"2012","journal-title":"J Pediatr Psychol"},{"key":"e_1_2_11_22_1","first-page":"145","article-title":"Sleep quality and its correlates in children with asthma: a cross\u2010sectional study","volume":"60","author":"Li L","year":"2019","journal-title":"Sleep Med"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S134864"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2018"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01376-8"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12360"},{"issue":"4","key":"e_1_2_11_27_1","article-title":"Causal associations between sleep traits and asthma: a mendelian randomization study","volume":"54","author":"Zhu Z","year":"2019","journal-title":"Eur Respir J"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203482"},{"issue":"1","key":"e_1_2_11_29_1","article-title":"Genetic determinants of sleep traits and their associations with health outcomes","volume":"12","author":"Zhu Z","year":"2021","journal-title":"Nat Commun"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu328"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000559"},{"key":"e_1_2_11_32_1","volume-title":"A Clinical Guide to Pediatric Sleep: Diagnosis and Management of Sleep Problems","author":"Mindell JA","year":"2015"},{"issue":"3","key":"e_1_2_11_33_1","first-page":"273","article-title":"Sleep\u2010disordered breathing and childhood asthma: a systematic review and meta\u2010analysis","volume":"29","author":"Papoutsakis C","year":"2018","journal-title":"Pediatr Allergy Immunol"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.70446","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:22:50Z","timestamp":1789539770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.70446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/pai.70446"],"URL":"https:\/\/doi.org\/10.1111\/pai.70446","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70446"}}