{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:49:28Z","timestamp":1792874968643,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic oesophagitis (EoE) is a chronic immune\u2010mediated disease in which oesophageal microbiota may vary according to disease activity and treatment. We aimed to characterise oesophageal microbiota in treatment\u2010na\u00efve children with EoE before and after proton pump inhibitor (PPI) therapy, and to assess spatial variability along the oesophagus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicentre longitudinal study, oesophageal biopsies were obtained from proximal\u2013mid and distal oesophagus of treatment\u2010na\u00efve children with newly diagnosed EoE at baseline and after standardised PPI induction therapy, and from non\u2010EoE controls. Microbiota composition was analysed using 16S rRNA gene sequencing. Alpha and beta diversity, differential taxonomic abundance and associations with eosinophilic inflammation and treatment response were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Oesophageal microbiota profiles differed between active EoE, post\u2010treatment EoE and non\u2010EoE controls. Active EoE showed higher alpha diversity, particularly in the presence of moderate\u2010to\u2010severe eosinophilic inflammation. Microbial diversity and composition were largely consistent between proximal\u2013mid and distal oesophageal regions. Active EoE was associated with enrichment of inflammation\u2010related taxa, including Fusobacteriota and Bacteroidota, and genera such as\n                      <jats:italic>Neisseria<\/jats:italic>\n                      ,\n                      <jats:italic>Fusobacterium<\/jats:italic>\n                      and\n                      <jats:italic>Prevotella<\/jats:italic>\n                      . PPI induction therapy was associated with reduced alpha diversity and compositional shifts characterised by increased Firmicutes and reduced inflammation\u2010associated genera, irrespective of histological response. Specific taxa were enriched in non\u2010responders post\u2010treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with EoE exhibit an oesophageal microbiota profile associated with disease activity and largely stable across oesophageal regions. PPI therapy was associated with microbiota compositional changes irrespective of histological response, supporting a dynamic interaction between treatment, inflammation and the oesophageal microbial ecosystem.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70452","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:29:31Z","timestamp":1786692571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Distinct oesophageal microbiota is associated with paediatric eosinophilic oesophagitis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-6447","authenticated-orcid":false,"given":"Silvia","family":"Rodr\u00edguez\u2010Manch\u00f3n","sequence":"first","affiliation":[{"name":"Paediatric Gastroenterology and Nutrition Department Hospital Infantil Universitario Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Alarc\u00f3n\u2010Cavero","sequence":"additional","affiliation":[{"name":"Department of Microbiology Hospital Universitario de La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Mira\u2010Obrador","sequence":"additional","affiliation":[{"name":"FISABIO Foundation Centre for Advanced Research in Public Health  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0313-7072","authenticated-orcid":false,"given":"Carolina","family":"Guti\u00e9rrez\u2010Junquera","sequence":"additional","affiliation":[{"name":"Paediatric Gastroenterology Unit Hospital Universitario Puerta de Hierro  Majadahonda 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