{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:54:32Z","timestamp":1793656472719,"version":"4.5.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The timing of clinically meaningful benefit after pediatric sublingual immunotherapy (SLIT) across allergic multimorbidity patterns remains uncertain. We evaluated early and longitudinal response to SLIT in routine care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective longitudinal cohort included patients aged 3\u201317\u2009years who received individualized liquid\u2010drop SLIT and met prespecified adherence and treatment\u2010persistence criteria. Assessments were performed at baseline and months 6, 12, 18, 24, and 36. The primary outcome was achievement of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) minimal clinically important difference (MCID; increase \u22650.5 points) at month 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1208 patients, 1095 had asthma and 954 allergic rhinitis. Overall, 666\/1095 (60.8%) achieved month\u20106 PAQLQ MCID: 515\/671 (76.8%) with asthma plus allergic rhinitis (Asthma+AR), 103\/254 (40.6%) with allergic asthma without AR, and 48\/170 (28.2%) with asthma, AR, and atopic dermatitis (Asthma+AR\u2009+\u2009AD). Compared with allergic asthma without AR, adjusted odds of response were higher for Asthma+AR (adjusted odds ratio 4.73, 95% CI 3.47\u20136.45) and lower for Asthma+AR\u2009+\u2009AD (0.52, 95% CI 0.34\u20130.80). By month 36, mean PAQLQ increased by 1.42 points, rhinitis\u2010related quality\u2010of\u2010life scores decreased by 1.89 points, FeNO decreased by 15.7\u2009ppb, and prescribed inhaled corticosteroid dose decreased by 92.6%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early response to pediatric SLIT differed across clinical allergic multimorbidity patterns, although outcomes continued to improve through 36\u2009months in this selected adherent and treatment\u2010persistent cohort.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/pai70462-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pai.70462","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:45:48Z","timestamp":1786693548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early and longitudinal response to sublingual immunotherapy across pediatric allergic multimorbidity patterns: A 3\u2010year real\u2010world cohort study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-7108","authenticated-orcid":false,"given":"Victor","family":"Gonzalez\u2010Uribe","sequence":"first","affiliation":[{"name":"AlergiaMx  Mexico City Mexico"},{"name":"Facultad Mexicana de Medicina Universidad La Salle  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7455-002X","authenticated-orcid":false,"given":"Jimena","family":"Prieto\u2010Gomez","sequence":"additional","affiliation":[{"name":"AlergiaMx  Mexico City Mexico"},{"name":"Facultad Mexicana de Medicina Universidad La Salle  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7705-6162","authenticated-orcid":false,"given":"Sebastian","family":"Moreno\u2010Castro","sequence":"additional","affiliation":[{"name":"AlergiaMx  Mexico City Mexico"},{"name":"Facultad Mexicana de Medicina Universidad La Salle  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5175-3828","authenticated-orcid":false,"given":"Ricardo","family":"Martinez\u2010Tenopala","sequence":"additional","affiliation":[{"name":"AlergiaMx  Mexico City Mexico"},{"name":"Hospital Infantil de M\u00e9xico Federico G\u00f3mez  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6723-3228","authenticated-orcid":false,"given":"Maria Julia","family":"Rendon\u2010Salazar","sequence":"additional","affiliation":[{"name":"AlergiaMx  Mexico City Mexico"},{"name":"Hospital \u00c1ngeles Lomas  Huixquilucan State of Mexico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8630-7889","authenticated-orcid":false,"given":"Tamara","family":"Hernandez\u2010Hernandez","sequence":"additional","affiliation":[{"name":"AlergiaMx  Mexico City Mexico"},{"name":"Facultad Mexicana de Medicina Universidad La Salle  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3604-485X","authenticated-orcid":false,"given":"Zaira Selene","family":"Mojica\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"AlergiaMx  Mexico 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