{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:01:01Z","timestamp":1790359261300,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Food allergy involves type 2 immune activation and epithelial\u2010barrier dysfunction beyond the gut and airway. Whether IgE\u2010mediated food allergy is associated with upper urinary tract disorders in children, and whether any association is anatomically specific is unknown.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In a frequency\u2010matched cross\u2010sectional study using Israeli health\u2010maintenance organization records (2001\u20132025), 879 children (<16\u2009years) with allergist\u2010confirmed IgE\u2010mediated food allergy were matched 1:4 to 3516 controls on age, sex, population sector, socioeconomic status, and body mass index. The primary outcome was a composite of upper urinary tract disorders (vesicoureteral reflux [VUR], hydronephrosis, or acute pyelonephritis); lower urinary tract and genital conditions served as negative controls. Odds ratios were estimated by logistic regression, adjusted for atopic dermatitis and asthma.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The upper\u2010tract composite was more prevalent with food allergy (4.0% vs. 1.1%; OR 3.9, 95% CI 2.4\u20136.2). VUR (OR 12.1), hydronephrosis (OR 2.6), and acute pyelonephritis (OR 9.4) were each increased; lower urinary tract (OR 1.2) and genital conditions were not. Urology visit rates were similar between groups. After adjustment for atopic dermatitis and asthma, VUR (adjusted OR 9.2, 95% CI 4.5\u201316.5) and the composite (aOR 2.1) remained elevated, whereas hydronephrosis and pyelonephritis attenuated. Early\u2010life antibiotic exposure was only modestly higher (aOR 1.2).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n IgE\u2010mediated food allergy was associated with upper, but not lower, urinary tract disorders; the VUR association was independent of atopic comorbidity. Because these anomalies are congenital, the pattern likely reflects shared susceptibility rather than causation, warranting prospective study.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.70481","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:00:16Z","timestamp":1789578016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["IgE<\/scp>\n \u2010mediated food allergy and upper urinary tract disorders in children: A matched study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7713-423X","authenticated-orcid":false,"given":"Eli","family":"Magen","sequence":"first","affiliation":[{"name":"Leumit Health Services Tel Aviv\u2010Yafo Israel"},{"name":"Adelson School of Medicine Ariel University Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Magen","sequence":"additional","affiliation":[{"name":"Urology Department, Assuta Ashdod University Hospital, Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Merzon","sequence":"additional","affiliation":[{"name":"Leumit Health Services Tel Aviv\u2010Yafo Israel"},{"name":"Adelson School of Medicine Ariel University Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-7152","authenticated-orcid":false,"given":"Ilan","family":"Green","sequence":"additional","affiliation":[{"name":"Leumit Health Services Tel Aviv\u2010Yafo Israel"},{"name":"Department of Family Medicine, Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2406-6402","authenticated-orcid":false,"given":"Avivit","family":"Golan\u2010Cohen","sequence":"additional","affiliation":[{"name":"Leumit Health Services Tel Aviv\u2010Yafo Israel"},{"name":"Department of Family Medicine, Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Vinker","sequence":"additional","affiliation":[{"name":"Leumit Health Services Tel Aviv\u2010Yafo Israel"},{"name":"Department of Family Medicine, Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Israel","sequence":"additional","affiliation":[{"name":"Leumit Health Services Tel Aviv\u2010Yafo Israel"},{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health, Faculty of Medical and Health Sciences Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-090122-043501"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.03.015"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxae002"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2023.07.001"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-023-06173-9"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13221866"},{"issue":"2","key":"e_1_2_13_8_1","first-page":"11840","article-title":"Are children with food allergies more likely to have lower urinary tract symptoms? A case\u2010control study","volume":"31","author":"Peard LM","year":"2024","journal-title":"Can J Urol"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15902"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181d61eeb"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.822"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00742-9"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2024.102493"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16429"},{"issue":"11","key":"e_1_2_13_16_1","first-page":"735","article-title":"Uropathogen and host responses in pyelonephritis","volume":"19","author":"Hreha TN","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0983"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-03685-y"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm15083086"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.12.005"},{"issue":"6","key":"e_1_2_13_21_1","doi-asserted-by":"crossref","first-page":"S326","DOI":"10.1016\/j.jacr.2024.02.025","article-title":"ACR appropriateness criteria\u00ae urinary tract infection\u2010child: 2023 update","volume":"21","author":"Expert Panel on Pediatric Imaging","year":"2024","journal-title":"J Am Coll Radiol"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.70481","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:33:05Z","timestamp":1790357585000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.70481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/pai.70481"],"URL":"https:\/\/doi.org\/10.1111\/pai.70481","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70481"}}