{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:28:38Z","timestamp":1793672918033,"version":"4.5.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The natural history of peanut allergy based on oral food challenge (OFC) outcomes has been rarely reported. We investigated the clinical course of peanut allergy up to 12\u2009years of age using OFC results.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The participants were children diagnosed with peanut allergy by 3\u2009years of age, defined by peanut sensitization with definitive immediate\u2010type symptoms or a positive OFC. Stepwise OFCs were performed on separate days with total ingestion amounts of 0.5, 3, and 10\u2009g of peanut. Tolerance was assessed through regular OFCs and defined as a negative result on a 10\u2010g OFC or the ability to consume \u226510\u2009g of peanut. We retrospectively analyzed OFC outcomes up to 12\u2009years of age.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We included 42 children (81% male) with a median peanut\u2010specific IgE (sIgE) of 16.8 kU\n A<\/jats:sub>\n \/L at age 3; 16 children (38%) had a history of anaphylaxis. Overall, 82 OFCs were performed; four children (10%) discontinued follow\u2010up. Kaplan\u2013Meier\u2013estimated tolerance acquisition rates were 2%, 18%, and 36% at 4, 6, and 12\u2009years of age, respectively. Compared with the non\u2010tolerant group, the tolerant group had lower peanut\u2010sIgE at 3\u2009years of age (median: 3.67 vs. 27.6 kU\n A<\/jats:sub>\n \/L; adjusted HR for log\u2010transformed value: 0.31, 95% CI: 0.10\u20130.96,\n p<\/jats:italic>\n \u2009=\u2009.041), and lower peanut\u2010sIgE at 6\u2009years and Ara h 2\u2010sIgE at 6 and 9\u2009years of age.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n One\u2010third of Japanese children diagnosed with peanut allergy by 3\u2009years of age achieved tolerance by 12\u2009years of age. Lower peanut\u2010sIgE levels at 3 years of age were associated with subsequent tolerance acquisition.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.70489","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:50:06Z","timestamp":1790995806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peanut allergy prognosis up to age 12: Oral food challenge\u2010based study in Japanese children"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1760-6225","authenticated-orcid":false,"given":"Kaito","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"},{"name":"Department of Pediatrics St. Marianna University School of Medicine Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-9044","authenticated-orcid":false,"given":"Ken\u2010ichi","family":"Nagakura","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-8135","authenticated-orcid":false,"given":"Naoko","family":"Fusayasu","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-7386","authenticated-orcid":false,"given":"Kyohei","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3674-0759","authenticated-orcid":false,"given":"Sakura","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-558X","authenticated-orcid":false,"given":"Motohiro","family":"Ebisawa","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St. Marianna University School of Medicine Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-744X","authenticated-orcid":false,"given":"Noriyuki","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.06.029"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.05.026"},{"key":"e_1_2_13_4_1","first-page":"1032","article-title":"National survey of immediate type food allergies in Japan in 2020: a report supported by a grant from the consumer affairs agency, government of Japan","volume":"72","author":"Sugizaki C","year":"2023","journal-title":"Arerugi"},{"key":"e_1_2_13_5_1","first-page":"120","article-title":"Current situation of anaphylaxis in Japan: data from the anaphylaxis registry of training and teaching facilities certified by the Japanese Society of Allergy","volume":"71","author":"Sato S","year":"2022","journal-title":"Arerugi"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2003.00072.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.040"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.10.005"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.11.024"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486311"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-10-12"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60513-3"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489337"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.01.002"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16111"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.026"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112129"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000516811"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2020.03.004"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.10.010"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14031"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2019.10.001"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000458724"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12823"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2020.100472"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12959"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2024.09.006"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2024.01.004"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14064"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12898"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pai.70489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.70489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:24:14Z","timestamp":1793672654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.70489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/pai.70489"],"URL":"https:\/\/doi.org\/10.1111\/pai.70489","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70489"}}