{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:29:24Z","timestamp":1793672964687,"version":"4.5.1"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To determine whether the timing and continuity of neonatal cow's milk formula (CMF) exposure influence the risk of IgE\u2010mediated cow's milk protein allergy (CMPA).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective case\u2013control study included 376 children (182 with CMPA and 194 healthy controls). Early feeding patterns\u2014including timing of CMF initiation and duration of exposure\u2014were evaluated. Multivariable logistic regression analyses were performed to assess independent risk factors while adjusting for potential confounders.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among infants exposed to cow's milk formula within the first 72\u2009h, discontinuation within 14\u2009days was associated with higher odds of CMPA than continued exposure for \u226515\u2009days (aOR: 8.07; 95% CI: 3.20\u201320.36;\n p<\/jats:italic>\n \u2009<\u2009.001). In contrast, continuous exposure (\u226515\u2009days) was associated with substantially lower odds of CMPA, independent of delivery mode.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Not early exposure per se, but brief and discontinuous exposure appears to drive sensitization. These findings highlight a critical \u201cwindow of vulnerability\u201d in early life, suggesting that unnecessary short\u2010term formula supplementation should be avoided, while continuous exposure\u2014if initiated\u2014may support oral tolerance development and may have immediate implications for neonatal feeding practices and allergy prevention strategies.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.70497","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:31:28Z","timestamp":1791185488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010term early exposure to cow's milk formula increases the risk of cow's milk allergy: A critical window in early life"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4422-7595","authenticated-orcid":false,"given":"Ayse","family":"Pakel","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-5053","authenticated-orcid":false,"given":"Handan","family":"Duman Senol","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9260-8157","authenticated-orcid":false,"given":"Ezgi","family":"Topyildiz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5373-8007","authenticated-orcid":false,"given":"Mehmet","family":"Geyik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Ceren","family":"Eser","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Figen","family":"Gulen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Ege University Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esen","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy, Faculty of Medicine Ege University Izmir 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