{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:56:58Z","timestamp":1791446218321,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["201414009A"],"award-info":[{"award-number":["201414009A"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Tropomyosin (Pen a 1)\u2010specific IgE (sIgE) is a proposed diagnostic marker for shrimp allergy; however, its superiority over crude shrimp sIgE is unclear. This study aimed to determine whether Pen a 1 sIgE is superior to crude shrimp sIgE for predicting oral food challenge (OFC) outcomes in children.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We retrospectively analyzed children who underwent OFCs using \u226540\u2009g heated shrimp and had both shrimp sIgE and Pen a 1 sIgE data. Areas under the receiver operating characteristic curves (AUCs) were compared using the DeLong test, and the paired AUC difference with its 95% confidence interval (CI) was estimated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 204 patients (median age 6.2\u2009years; 70% male), 33 (16%) had a positive OFC. The AUCs for shrimp sIgE (0.629; 95% CI, 0.535\u20130.723) and Pen a 1 sIgE (0.622; 95% CI, 0.524\u20130.718) did not differ significantly (difference, 0.007; 95% CI, \u22120.069 to 0.083; DeLong\n p<\/jats:italic>\n \u2009=\u2009.850). Pen a 1 sIgE correlated strongly with shrimp sIgE (\n r<\/jats:italic>\n \u2009=\u2009.767,\n p<\/jats:italic>\n \u2009<\u2009.001). Among 190 patients with\n Dermatophagoides pteronyssinus<\/jats:italic>\n (Der p) sIgE data, Der p sIgE correlated weakly with both markers (\n r<\/jats:italic>\n =\u2009.321 and .217) and did not differ by OFC outcome (\n p<\/jats:italic>\n \u2009=\u2009.612).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Superiority of Pen a 1 sIgE over crude shrimp sIgE was not demonstrated. The strong correlation suggests that tropomyosin is a major IgE\u2010binding component of the crude extract. OFC remains essential.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.70506","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:48:46Z","timestamp":1791445726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No demonstrated superiority of tropomyosin (Pen a 1) sIgE over crude shrimp sIgE in children"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-744X","authenticated-orcid":false,"given":"Noriyuki","family":"Yanagida","sequence":"first","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironaga","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-3628","authenticated-orcid":false,"given":"Kanako","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"},{"name":"Department of Dermatology Kobe City Hospital Organization Kobe City Medical Center West Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-9044","authenticated-orcid":false,"given":"Ken\u2010ichi","family":"Nagakura","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-7386","authenticated-orcid":false,"given":"Kyohei","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0317-1089","authenticated-orcid":false,"given":"Kiyotake","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3674-0759","authenticated-orcid":false,"given":"Sakura","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-558X","authenticated-orcid":false,"given":"Motohiro","family":"Ebisawa","sequence":"additional","affiliation":[{"name":"Department of Allergy, Clinical Research Center for Allergy and Rheumatology NHO Sagamihara National Hospital Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jaci.2004.04.018","article-title":"Prevalence of seafood allergy in the United States determined by a random telephone survey","volume":"114","author":"Sicherer SH","year":"2004","journal-title":"J Allergy Clin 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