{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:47:57Z","timestamp":1792043277990,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Intranasal adrenaline has been approved in multiple countries for anaphylaxis treatment, based primarily on pharmacokinetic\/pharmacodynamic comparisons to adrenaline autoinjectors (AAIs).<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To assess patient and caregiver perspectives regarding emerging non\u2010injectable adrenaline routes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Online survey of adults and caregivers of children with food allergy prescribed AAIs, with international dissemination supported by the European Academy of Allergy and Clinical Immunology (February\u2013April 2025).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We analyzed 542 responses from caregivers and 224 from adults with food allergy. Effectiveness of adrenaline nasal spray (ANS) compared to AAI was rated \u201cextremely important\u201d by 78% of caregivers and 71% of adults. 48% of caregivers and 42% of adults were \u201cextremely worried\u201d that ANS may not work as well as AAI, and 50% and 44% (respectively) that it may not work well enough. Compared with AAI, respondents were less worried about ANS being painful or difficult to carry, and about fear\/embarrassment around use, but more worried about side effects and knowing how to use it. Most anticipated being more comfortable using ANS than AAI, and over half anticipated earlier use during anaphylaxis. Only 17.2% of caregivers and 23.2% of adults preferred to be prescribed ANS only. There was interest in sublingual adrenaline due to portability and reduced needle\u2010related burden, but confidence depended on comparable speed\/effectiveness and feasibility during reactions.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Non\u2010injectable adrenaline is attractive to caregivers and adults, and may improve willingness to carry and use adrenaline. However, demand for evidence of effectiveness, safety, and real\u2010world feasibility is high, highlighting important information needs for shared decision\u2010making.<\/jats:p>\n \n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pai.70507","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:17:28Z","timestamp":1792041448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["International survey of parental and patient perspectives on emerging adrenaline devices for community\u2010based management of anaphylaxis: An EAACI task force report"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7909-748X","authenticated-orcid":false,"given":"M. F.","family":"Gonzalez\u2010Matamala","sequence":"first","affiliation":[{"name":"Centro del Alergico Santiago de Chile Chile"},{"name":"Allergy Department Hospital Cl\u00ednic Barcelona Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Patel","sequence":"additional","affiliation":[{"name":"Section of Inflammation, Repair and Development, National Heart and Lung Institute Imperial College London London UK"},{"name":"Department of Paediatric Allergy Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Kahn\u2010Santoro","sequence":"additional","affiliation":[{"name":"Allergy MSc Alumni, National Heart and Lung Institute Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5561-0904","authenticated-orcid":false,"given":"R.","family":"Knibb","sequence":"additional","affiliation":[{"name":"Institute of Health and Neurodevelopment Aston University Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-1248","authenticated-orcid":false,"given":"G.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Southampton Southampton UK"},{"name":"University Hospital Southampton NHS Foundation Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9862-5161","authenticated-orcid":false,"given":"P. 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Lille CHU de Lille, Service de Pneumologie et d'Allergologie P\u00e9diatrique Lille France"},{"name":"H\u00f4pital Jeanne de Flandre Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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