{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:19:05Z","timestamp":1782512345272,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,6]],"date-time":"2012-10-06T00:00:00Z","timestamp":1349481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether perioperative serum levels of oxidative stress markers, thiobarbituric acid reactive substances (<jats:styled-content style=\"fixed-case\">TBARS<\/jats:styled-content>), and carbonyl moieties are associated with outcomes in children after heart surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Oxidative stress markers are increased following heart surgery with cardiopulmonary bypass (<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>) and can play a role in ischemia\u2013reperfusion injury, but its associations with myocardial dysfunction, low cardiac output syndrome (<jats:styled-content style=\"fixed-case\">LCOS<\/jats:styled-content>), and outcomes are not proven.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective secondary analysis of a cohort study comprising 55 children (median age, 109 [2\u2013611] days), we compared pre\u2010, intra\u2010 and postoperative serum levels of <jats:styled-content style=\"fixed-case\">TBARS<\/jats:styled-content> and carbonyl moieties among patients with and without postoperative <jats:styled-content style=\"fixed-case\">LCOS<\/jats:styled-content>, cyanotic and acyanotic congenital heart disease (<jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>), and survivors and nonsurvivors. We also assessed the independent effect of TBARS and carbonyl moieties peak levels on the mortality\u2010adjusted hospital length of stay (a<jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients who developed postoperative <jats:styled-content style=\"fixed-case\">LCOS<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a036) were significantly younger, more frequently cyanotic, more severely ill, and underwent more complex procedures with longer <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>. However, <jats:styled-content style=\"fixed-case\">TBARS<\/jats:styled-content> and carbonyl moieties serum levels did not change significantly over time. Moreover, they were not significantly different in patients with or without <jats:styled-content style=\"fixed-case\">LCOS<\/jats:styled-content>, cyanotic and acyanotic <jats:styled-content style=\"fixed-case\">CHD<\/jats:styled-content>, or survivors and nonsurvivors. There was a significant correlation between <jats:styled-content style=\"fixed-case\">TBARS<\/jats:styled-content> and tumor necrosis factor <jats:italic>alpha<\/jats:italic> (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) peak serum levels. Neither <jats:styled-content style=\"fixed-case\">TBARS<\/jats:styled-content> nor carbonyl moieties peak serum levels were independently associated with a<jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, oxidative stress markers <jats:styled-content style=\"fixed-case\">TBARS<\/jats:styled-content> and carbonyl moieties were not associated with the development of <jats:styled-content style=\"fixed-case\">LCOS<\/jats:styled-content>, the a<jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>, or mortality in children after heart surgery with <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12040","type":"journal-article","created":{"date-parts":[[2012,10,6]],"date-time":"2012-10-06T05:51:11Z","timestamp":1349502671000},"page":"188-194","source":"Crossref","is-referenced-by-count":22,"title":["Oxidative stress markers are not associated with outcomes after pediatric heart surgery"],"prefix":"10.1111","volume":"23","author":[{"given":"Paulo H.","family":"Manso","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Hospital das Cl\u00ednicas, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Carmona","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine Department of Pediatrics, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Dal\u2010Pizzol","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathophysiology University of Southern Santa Catarina Crici\u00fama Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcia","family":"Petronilho","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathophysiology University of Southern Santa Catarina Crici\u00fama Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathophysiology University of Southern Santa Catarina Crici\u00fama Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Castro","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine, Faculty of Medicine of Ribeir\u00e3o Preto, University of S\u00e3o Paulo Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P. 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