{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:28:59Z","timestamp":1778797739606,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T00:00:00Z","timestamp":1350259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Aim of sedation during pediatric urodynamic studies (<jats:styled-content style=\"fixed-case\">UDS<\/jats:styled-content>) is a calm and cooperative child while not affecting measurements. We compared the effectiveness of midazolam to low\u2010dose ketamine infusion for sedation and their impact on urodynamics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\u2010I children undergoing <jats:styled-content style=\"fixed-case\">UDS<\/jats:styled-content> were randomly assigned to group K (ketamine) loading dose (0.25\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) followed by infusion of 10\u201320\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> or group <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> (midazolam) loading dose of (0.02\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>) followed by 1\u20132\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>. The sedation scores and reactivity to catheterization were monitored by <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hildren <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital of <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>isconsin <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>edation <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale and <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>rankl <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ehavior <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ating <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale, respectively. The <jats:styled-content style=\"fixed-case\">UDS<\/jats:styled-content> included two\u2010channel filling cystometry in supine position followed by a free uroflowmetry in sitting position. The <jats:styled-content style=\"fixed-case\">UDS<\/jats:styled-content> was performed and interpreted in accordance with good urodynamic practice guidelines of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ontinence <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ociety (2002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 34 children were enrolled. <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content> children (<jats:italic>n<\/jats:italic>\u00a0=\u00a017) attained sedation earlier 6.80 (\u00b13.36) min vs. 9.40 (\u00b12.82) min; (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) than group M (<jats:italic>n<\/jats:italic>\u00a0=\u00a017) and also recovered earlier 11.60 (\u00b13.13) min vs. 19.67 (\u00b15.49) min (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Reactivity scores during urinary and rectal catheterization were lower in group K (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03 and 0.01), respectively. Historical <jats:styled-content style=\"fixed-case\">UDS<\/jats:styled-content> data of 21 participants were available for comparison with effect of medication. None of the study drugs affected <jats:styled-content style=\"fixed-case\">UDS<\/jats:styled-content> parameters significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Midazolam or low\u2010dose ketamine provide satisfactory sedation during pediatric <jats:styled-content style=\"fixed-case\">UDS<\/jats:styled-content> without impacting urodynamic values.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12046","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T07:04:43Z","timestamp":1350284683000},"page":"415-421","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of low\u2010dose ketamine to midazolam for sedation during pediatric urodynamic study"],"prefix":"10.1111","volume":"23","author":[{"given":"Arun K.","family":"Thevaraja","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yatindra Kumar","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sondekoppam V.","family":"Rakesh","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi B.","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katragadda L.N.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayank","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Urology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2010.03.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/BF01957153","article-title":"Distress and radiological investigations of the urinary tract in children","volume":"155","author":"Phillips D","year":"1996","journal-title":"Eur J Pediatr"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.1216"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-003-0874-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1996.04325.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01407.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.02099.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2252011786"},{"key":"e_1_2_6_10_1","first-page":"1","article-title":"Preincisional administration of intravenous or subcutaneous infiltration of low\u2010dose ketamine suppresses postoperative pain after appendectomy","volume":"5","author":"Honarmand A","year":"2012","journal-title":"J Pain Res"},{"key":"e_1_2_6_11_1","first-page":"774","article-title":"A study of low\u2010dose S\u2010Ketamine infusion as \u201cpreventive\u201d pain treatment for cesarean section with spinal anesthesia: benefits and side effects","volume":"78","author":"Suppa E","year":"2012","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2009.200"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.236"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.1995.tb00170.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.01.044"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1874-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.12.005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2006.02.007"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199808000-00042"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000176595.49213.13"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.18.1.34"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2007.02384.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02665.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66007-5"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90023-X"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2011.03609.x"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.12046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.12046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T08:36:07Z","timestamp":1700642167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.12046"}},"subtitle":[],"editor":[{"given":"Brian J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2012,10,15]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/pan.12046"],"URL":"https:\/\/doi.org\/10.1111\/pan.12046","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,15]]}}}