{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:09:28Z","timestamp":1785928168538,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,29]],"date-time":"2012-12-29T00:00:00Z","timestamp":1356739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Impairment of blood coagulation is one of the main side effects of volume replacement, particularly if artificial colloids such as hydroxyethyl starch (<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>) and gelatine preparations are used. This animal study aimed to evaluate the effect of a single fast intravenous crystalloid or colloid fluid bolus on blood coagulation as measured by rotation thromboelastometry (<jats:styled-content style=\"fixed-case\">ROTEM<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two anesthetized piglets were infused with a rapid 20\u00a0ml\u00b7kg<jats:sup>\u22121<\/jats:sup> fluid bolus of either normal saline (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>), 4% gelatine, 5% albumin or 6% <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> 130\/0.4 (<jats:italic>n<\/jats:italic>\u00a0=\u00a08 per group) over a period of 2\u00a0min. Hemostasis was assessed by <jats:styled-content style=\"fixed-case\">ROTEM<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> before and 1\u00a0min after fluid administration. Within\u2010group differences were analyzed by Wilcoxon test, and additionally overall Kruskal\u2013Wallis test followed by posthoc Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test were applied to detect differences between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All fluids caused a significant weakening of clot strength within groups. <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> and gelatine showed a significantly stronger impairment of clot growth and maximum clot firmness as compared with albumin and normal saline. Impairment of fibrin polymerization was more pronounced following <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> as compared with all other fluids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After moderate but very fast volume loading, <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> and gelatine impair blood coagulation to a larger extent as compared with albumin or normal saline, while no significant differences were observed between both artificial colloids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12106","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T11:59:17Z","timestamp":1356955157000},"page":"258-264","source":"Crossref","is-referenced-by-count":21,"title":["Effect of rapid fluid resuscitation using crystalloids or colloids on hemostasis in piglets"],"prefix":"10.1111","volume":"23","author":[{"given":"Jacqueline","family":"Mauch","sequence":"first","affiliation":[{"name":"Department of Anaesthesia University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caveh","family":"Madjdpour","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette P. N.","family":"Kutter","sequence":"additional","affiliation":[{"name":"Section of Anaesthesiology Equine Department Vetsuisse Faculty of the University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Spielmann","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regula","family":"Bettschart\u2010Wolfensberger","sequence":"additional","affiliation":[{"name":"Section of Anaesthesiology Equine Department Vetsuisse Faculty of the University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia University Children's Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318165dfbb"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq199"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2008.11.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819323c6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.00736.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-010-1034-y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000200285.20510.b6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.6.684"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328339384e"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05186.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200205000-00043"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e318165df18"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01863.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000061460.59320.B0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen350"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes098"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03022250"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200106000-00038"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200509000-00031"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03460.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000280481.18570.27"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2012.03798.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq173"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.05.015"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2011.03776.x"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.12106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.12106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T01:13:49Z","timestamp":1698628429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.12106"}},"subtitle":[],"editor":[{"given":"Brian","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2012,12,29]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/pan.12106"],"URL":"https:\/\/doi.org\/10.1111\/pan.12106","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,29]]}}}