{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:05:42Z","timestamp":1759565142323},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T00:00:00Z","timestamp":1360108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the efficacy of esmolol in protecting the myocardium from ischemia during pediatric cardiac surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Esmolol, an ultra\u2010short acting beta 1\u2010adrenoceptor blocker, reduces myocardial injury in adult cardiac operations. However, this technique is rarely used in pediatric cardiac surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty children with ventricular septal defect were randomly allocated to the esmolol group and the control group. Patients received intravenous esmolol (0.05\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> after tracheal intubation, 0.3 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> during cardiopulmonary bypass (CPB) and 0.03\u20130.05 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> until the end of surgery) or placebo, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma levels of creatine kinase\u2010MB, cardiac troponin I in the esmolol group 2 min after completion of CPB, at the end of surgery, 4\u00a0h after surgery, and the first postoperative day were significantly lower than those in the control group. Values of heart rate 10\u00a0min after induction, 2\u00a0min before institution of CPB, 2\u00a0min after completion of CPB, and at the end of surgery were significantly lower in the esmolol group; however, mean arterial pressure, CPB time, cross\u2010clamp time, and the rate of heart spontaneous rebeating were not statistically different between two groups. Cumulative postoperative dosage of dopamine in the esmolol group (100.1\u00a0\u00b1\u00a053.1\u00a0mg) was significantly less than that in the control group (171.4\u00a0\u00b1\u00a092.1\u00a0mg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Esmolol can protect the myocardium from ischemic injury during CPB in children and significantly reduce the use of inotropic drug.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12117","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T10:03:38Z","timestamp":1360145018000},"page":"217-221","source":"Crossref","is-referenced-by-count":4,"title":["Protective effect of esmolol on myocardial ischemic injury during open heart surgery in children"],"prefix":"10.1111","volume":"23","author":[{"given":"Ping","family":"Gui","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanglong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 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