{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:47:41Z","timestamp":1696225661379},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T00:00:00Z","timestamp":1368403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Perioperative acquired factor XIII<\/jats:styled-content> deficiency has been looked upon as a potential cause of postoperative bleeding in adult cardiac surgery.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010four infants were prospectively studied for the time course of factor XIII<\/jats:styled-content> in plasma and the effect on chest tube drainage (CTD<\/jats:styled-content>) and transfusion requirements in the first 24\u00a0h after surgery. A reconstituted blood prime (RBP<\/jats:styled-content>) with fresh\u2013frozen plasma (FFP<\/jats:styled-content>) and packed red blood cells (PRBC<\/jats:styled-content>) was used. Samples were taken at baseline, after cardiopulmonary bypass and upon arrival in the ICU<\/jats:styled-content>. Differences in blood loss and transfusion requirements based on a cutoff value of 70% factor XIII<\/jats:styled-content> activity at the time of ICU<\/jats:styled-content> admission were also calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>Baseline factor XIII<\/jats:styled-content> activity was 79%, decreased to 71% after CPB<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.102) and increased back up to 77% at ICU<\/jats:styled-content> arrival (P<\/jats:italic>\u00a0=\u00a00.708). There was no significant correlation between factor XIII<\/jats:styled-content>, CTD<\/jats:styled-content>, age, cyanosis, platelet count, and transfusion requirements at any time point. Only preoperative fibrinogen levels correlated significantly with factor XIII<\/jats:styled-content> activity. Perioperative blood transfusions (PRBC <\/jats:styled-content>P<\/jats:italic>\u00a0=\u00a00.712, FFP <\/jats:styled-content>P<\/jats:italic>\u00a0=\u00a00.909, platelets P<\/jats:italic>\u00a0=\u00a00.807) and chest tube losses (P<\/jats:italic>\u00a0=\u00a00.424 at 6\u00a0h and P<\/jats:italic>\u00a0=\u00a00.215 at 24\u00a0h) were not significantly different above or below a 70% factor XIII<\/jats:styled-content> activity at ICU<\/jats:styled-content> arrival.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Factor XIII<\/jats:styled-content> activity in infants with congenital heart defects is within the lower range of normal adults, independent of patient's age and the presence of cyanosis. Reconstituted blood prime maintains factor XIII<\/jats:styled-content> activity at sufficient levels during pediatric cardiac surgery. We could not detect a correlation between FXIII<\/jats:styled-content> and CTD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12193","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T13:55:59Z","timestamp":1368453359000},"page":"1035-1041","source":"Crossref","is-referenced-by-count":5,"title":["The perioperative course of factor XIII<\/scp> and associated chest tube drainage in newborn and infants undergoing cardiac surgery"],"prefix":"10.1111","volume":"23","author":[{"given":"Ralph","family":"Gertler","sequence":"first","affiliation":[{"name":"Institut f\u00fcr An\u00e4sthesiologie Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Martin","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr An\u00e4sthesiologie Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Hapfelmeier","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Statistik und Epidemiologie Klinikum rechts der Isar Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Tassani\u2010Prell","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr An\u00e4sthesiologie Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegmund","family":"Braun","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Laboratoriumsmedizin Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunther","family":"Wiesner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr An\u00e4sthesiologie Deutsches Herzzentrum M\u00fcnchen Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/ajplegacy.1944.142.4.581","article-title":"A study on the conversion of fibrinogen to fibrin","volume":"142","author":"Robbins KC","year":"1944","journal-title":"Am J Physiol Am Physiological Soc"},{"key":"e_1_2_9_3_1","first-page":"89","article-title":"Inheritance of deficiency of fibrin\u2010stabilizing factor (factor 13)","volume":"22","author":"Lorand L","year":"1970","journal-title":"Am J Hum Genet"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1182\/blood.V93.3.897","article-title":"Genotype\/phenotype correlations for coagulation factor XIII: specific normal polymorphisms are associated with high or low factor XIII specific activity","volume":"93","author":"Anwar R","year":"1999","journal-title":"Blood"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1975.tb00303.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-008-1360-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318194b21e"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1160\/TH08-12-0826","article-title":"Repletion of factor XIII following cardiopulmonary bypass using a recombinant A\u2010subunit homodimer. 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