{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:36:50Z","timestamp":1791815810116,"version":"4.3.4"},"reference-count":86,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Duchenne muscular dystrophy (\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      ) and Becker muscular dystrophy (\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      ) are associated with life\u2010threatening perioperative complications, including rhabdomyolysis, hyperkalemia, and hyperthermia. Current recommendations contraindicate use of succinylcholine and volatile anesthetics; however, the latter recommendation remains controversial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To review the perioperative outcomes of patients with\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed records of patients with\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      who underwent anesthetic management at our institution from January 1990 through December 2011.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 47 patients (\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      , 37;\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      , 10) who underwent 117 anesthetic exposures (\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      , 101;\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      , 16). Volatile anesthetic agents were used 66 times (\n                      <jats:styled-content style=\"fixed-case\">DMD<\/jats:styled-content>\n                      , 59;\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      , 7). One patient with undiagnosed\n                      <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>\n                      received succinylcholine and developed acute rhabdomyolysis and hyperkalemic cardiac arrest. All other major complications were attributed to the procedure (i.e., large bleeding), to preexisting comorbidities (i.e., respiratory failure, cardiac disease), or to both.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Use of succinylcholine in children with dystrophinopathy is contraindicated. These patients have significant comorbidities and are frequently undergoing extensive operations; complications related to these factors can develop, as evidenced by our series. These complications may occur with use of volatile and nonvolatile anesthetics. However, because most of our patients were older than 8\u00a0years at the time of surgery, our observation cannot be generalized to younger dystrophin\u2010deficient children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pan.12248","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T17:18:53Z","timestamp":1375809533000},"page":"855-864","source":"Crossref","is-referenced-by-count":81,"title":["Anesthesia and Duchenne or Becker muscular dystrophy: review of 117 anesthetic exposures"],"prefix":"10.1111","volume":"23","author":[{"given":"Leal G.","family":"Segura","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica D.","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Medical Center Anesthesiologists Des Moines IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby N.","family":"Weingarten","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Scavonetto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Bojani\u0107","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Neonatology University Hospital Merkur Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Selcen","sequence":"additional","affiliation":[{"name":"Department of Neurology Division of Child and Adolescent Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Sprung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq036"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.4.795"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.01.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068446"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2007.02302.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1542\/peds.71.1.118","article-title":"Malignant hyperthermia in a child with Duchenne muscular dystrophy","volume":"71","author":"Kelfer HM","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200012000-00030"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(94)E0026-5"},{"key":"e_1_2_8_10_1","first-page":"423","article-title":"[Malignant hyperthermia of Duchenne muscular dystrophy: application of clinical grading scale and caffeine contracture of skinned muscle fibers]","volume":"40","author":"Takagi A","year":"2000","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03010977"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198302000-00013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.1997.d01-41.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03013547"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1992.tb12344.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/52.5.559-a"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9402200518"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2448"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2952J"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e3283566789"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4065\/74.4.330"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(200002)29:2<141::AID-PPUL9>3.0.CO;2-Y"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000007039"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62226-X"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199802000-00013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0750-7658(86)80073-9"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/014556139307200206","article-title":"Sudden cardiac arrest during adenotonsillectomy in a patient with subclinical Duchenne's muscular dystrophy","volume":"72","author":"Benton NC","year":"1993","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03015422"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005341"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/54.12.1331"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03013811"},{"key":"e_1_2_8_32_1","first-page":"497","article-title":"[Cardiac arrest during anesthesia induction with halothane and succinylcholine in an infant. Massive hyperkalemia and rhabdomyolysis in suspected myopathy and\/or malignant hyperthermia]","volume":"40","author":"Mehler J","year":"1991","journal-title":"Anaesthesist"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197802000-00012"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(96)00171-3"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/49.5.495"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80612-X"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/58.5.576"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03011544"},{"key":"e_1_2_8_39_1","first-page":"165","article-title":"Succinylcholine\u2010induced cardiac arrest in unsuspected Becker muscular dystrophy: a case report","volume":"36","author":"Wu CC","year":"1998","journal-title":"Acta Anaesthesiol Sin"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/43.10.984"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03007752"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(70)90523-3"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(91)90025-N"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307388700200214"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03027134"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198803000-00028"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2004.00596.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(89)90129-8"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.1999.00835.x"},{"key":"e_1_2_8_50_1","first-page":"437","article-title":"[Anesthesia with sevoflurane for tonsillectomy in a boy with Duchenne muscular dystrophy]","volume":"53","author":"Vieito M","year":"2006","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1990.tb14497.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01698.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310100812"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000146533.21771.2F"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000280935.90260.d0"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq035"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198711000-00051"},{"key":"e_1_2_8_58_1","first-page":"495","article-title":"[Detection of a Duchenne muscular dystrophy: postanesthetic cardiocirculatory arrest]","volume":"35","author":"Sicard A","year":"1987","journal-title":"Cah Anesthesiol"},{"key":"e_1_2_8_59_1","first-page":"190","article-title":"[Sevoflurane can induce rhabdomyolysis in Duchenne's muscular dystrophy]","volume":"51","author":"Takahashi H","year":"2002","journal-title":"Masui"},{"key":"e_1_2_8_60_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1177\/0310057X9502300521","article-title":"Cardiac arrest during major spinal scoliosis surgery in a patient with Duchenne's muscular dystrophy undergoing intravenous anaesthesia","volume":"23","author":"Irwin MG","year":"1995","journal-title":"Anaesth Intensive Care"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg116"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150512"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181aa5cf6"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880150110"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/79.1.125"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(91)90060-A"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200201000-00036"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01801.x"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03013541"},{"key":"e_1_2_8_70_1","first-page":"22","article-title":"Anesthesia for muscle dystrophy patients","volume":"43","author":"Cobham IG","year":"1964","journal-title":"Anesth Analg"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3710"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(97)00109-8"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2004.027383"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000287009.46896.a7"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589803500205"},{"key":"e_1_2_8_76_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/clinchem\/46.4.577","article-title":"Propofol\u2010associated rhabdomyolysis with cardiac involvement in adults: chemical and anatomic findings","volume":"46","author":"Stelow EB","year":"2000","journal-title":"Clin Chem"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10053"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200404000-00017"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.1.301"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X7200100209"},{"key":"e_1_2_8_81_1","first-page":"274","article-title":"[A case of Duchenne muscular dystrophy showing coagulation cascade activation induced by muscle destruction due to convulsion]","volume":"43","author":"Saito T","year":"2003","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200103)24:3<399::AID-MUS1012>3.0.CO;2-B"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00173371"},{"key":"e_1_2_8_84_1","first-page":"513","article-title":"Duchenne muscular dystrophy (DMD) in a female with an X\/autosome translocation: further evidence that the DMD locus is at Xp21","volume":"33","author":"Jacobs PA","year":"1981","journal-title":"Am J Hum Genet"},{"key":"e_1_2_8_85_1","first-page":"173","article-title":"Turner's syndrome and Duchenne muscular dystrophy in a girl with an X; autosome translocation","volume":"27","author":"Bjerglund Nielsen L","year":"1984","journal-title":"Ann Genet"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131496"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.5.389"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.12248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.12248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T21:34:03Z","timestamp":1694640843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.12248"}},"subtitle":[],"editor":[{"given":"Barbara","family":"Brandom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,6]]},"references-count":86,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/pan.12248"],"URL":"https:\/\/doi.org\/10.1111\/pan.12248","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,6]]}}}