{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:10:57Z","timestamp":1782601857695,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T00:00:00Z","timestamp":1386720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine whether the<jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content><jats:sub>EI<\/jats:sub>and<jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content><jats:sub>awake<\/jats:sub>of sevoflurane in infants with obstructive jaundice are different from that observed in nonjaundiced infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants scheduled for abdominal surgery were recruited into the study. General anesthesia was induced with 8% sevoflurane inhaled with 8\u00a0l\u00b7min<jats:sup>\u22121<\/jats:sup>of oxygen via mask, followed by adjustment of inspired sevoflurane to the target concentration based on the result in previous patient at which laryngoscopy and tracheal intubation were attempted and maintained for 15\u00a0min. All responses to tracheal intubation were assessed. At the end of the procedure, sevoflurane was titrated to the target concentration, which was kept constant for 15\u00a0min before a standard stimulus was applied to determine whether the infant was awake. The<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ixon's \u2018up and down\u2019 method was used to determine progression of subsequent concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference between the<jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content><jats:sub>EI<\/jats:sub>of sevoflurane in infants with obstructive jaundice (3.40\u00a0\u00b1\u00a00.21%) and that observed in the control group (3.43\u00a0\u00b1\u00a00.18%). But the<jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content><jats:sub>awake<\/jats:sub>of sevoflurane in jaundiced infants (1.00\u00a0\u00b1\u00a00.15%) was significantly lower than that of nonjaundiced controls (1.40\u00a0\u00b1\u00a00.21%;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004); to complement these findings, we reported a negative correlation between serum total bilirubin and the probability of awakening (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.984, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>is 0.970\u20130.998,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The<jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content><jats:sub>awake<\/jats:sub>of sevoflurane was reduced in obstructive jaundiced infants compared with nonjaundiced controls, whereas there was no significant difference between the<jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content><jats:sub>EI<\/jats:sub>of sevoflurane in infants with obstructive jaundice and that observed in nonjaundiced infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12322","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T13:45:55Z","timestamp":1386769555000},"page":"282-289","source":"Crossref","is-referenced-by-count":5,"title":["<scp>MAC<\/scp><sub>EI<\/sub>and<scp>MAC<\/scp><sub>awake<\/sub>of sevoflurane in infants with obstructive jaundice"],"prefix":"10.1111","volume":"24","author":[{"given":"Si\u2010Qin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Rong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of 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