{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:12:10Z","timestamp":1784027530490,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:00:00Z","timestamp":1390867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Aarhus University, Denmark"},{"DOI":"10.13039\/501100003035","name":"Aase and Ejnar Danielsens Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Danish Children's Heart Foundation, by The Danish Heart Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reduced hemostatic capacity is common following congenital heart surgery using cardiopulmonary bypass (<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>). The etiology is multifactorial with dilutional coagulopathy, as well as platelet adhesion and activation in the <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> circuit and oxygenator. The purpose of the present study was to evaluate platelet count and function in children following <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective, observational study comprising 40 children, platelet count and function (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ultiplate <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nalyzer<jats:sup>\u00ae<\/jats:sup>) were measured before surgery, immediately after bypass, and on the first postoperative day. Furthermore, conventional coagulation analysis and thromboelastometry (<jats:styled-content style=\"fixed-case\">ROTEM<\/jats:styled-content><jats:sup><jats:bold>\u00ae<\/jats:bold><\/jats:sup>) were carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant decrease in platelet count was observed immediately after coming of bypass (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.001) and persisted to the first postoperative day (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.002). Platelet function was reduced immediately after bypass after induction with <jats:styled-content style=\"fixed-case\">ADP<\/jats:styled-content> (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.001) or <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content> (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.03). The duration of <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> correlated significantly with the decrease in platelet count (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.62, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.0001) and reduction in platelet function (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.42\u20140.63; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.01). Moderate to deep hypothermia during <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> was associated with a decreased platelet function (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.01\u20130.12), whereas cyanosis or previous heart surgery caused no further changes in platelet function following <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both platelet count and platelet function were significantly reduced after <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> in children undertaken correctional heart surgery. Duration of <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> and hypothermia was associated with significant changes in platelet function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12347","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T04:58:39Z","timestamp":1390971519000},"page":"386-392","source":"Crossref","is-referenced-by-count":61,"title":["Marked changes in platelet count and function following pediatric congenital heart surgery"],"prefix":"10.1111","volume":"24","author":[{"given":"Jo","family":"B\u00f8nding Andreasen","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Centre for Haemophilia and Thrombosis Department of Clinical Biochemistry Aarhus University Hospital Aarhus N 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