{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:07:53Z","timestamp":1787782073308,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T00:00:00Z","timestamp":1389571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Erciyes University Scientific Research Projects Coordination Unit.","award":["ER\u00ef\u00bf\u00bd\/BAP, Project No:TSA-12-3882"],"award-info":[{"award-number":["ER\u00ef\u00bf\u00bd\/BAP, Project No:TSA-12-3882"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In this study we aimed to investigate the effects of dexmedetomidine on early stage renal function in pediatric patients undergoing cardiac angiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>60 pediatric patients between 6 and 72\u00a0months of age undergoing cardiac angiography were included in the study. Patients were divided into two groups. The patients in both groups were administered 1\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> ketamine, 1\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup> propofol as bolus and followed by 1\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup> ketamine and 50\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> propofol infusion. Additionally, a loading dose of 1\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup> dexmedetomidine given over 10\u00a0min followed by 0.5\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup> dexmedetomidine infusion to patients in group D. The patients were evaluated for <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>, creatinine, renin, endothelin\u20101, <jats:styled-content style=\"fixed-case\">TAS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TOS<\/jats:styled-content> blood levels before the procedure and 6th and 24th\u00a0h after the procedure. <jats:styled-content style=\"fixed-case\">pRIFLE<\/jats:styled-content> criteria were used to define <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> and its incidence in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to <jats:styled-content style=\"fixed-case\">pRIFLE<\/jats:styled-content> criteria contrast\u2010induced acute kidney injury developed in 3 (10%) of the patients in group D and 11 (36.7%) of the patients in group C (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.029, risk ratio\u00a0=\u00a00.27; 95% CI: 0.084\u20130.88). In patients who developed <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>, Endothelin\u20101 levels in groups C and D were significantly higher than baseline levels at 6th, 24th and 6th\u00a0h, respectively. Renin levels were significantly increased at 6th and 24 th<jats:sup>\u00a0<\/jats:sup>h in patients with <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dexmedetomidine may be beneficial in protecting against contrast\u2010induced nephropathy during pediatric angiography by preventing the elevation of vasoconstrictor agents such as plasma endothelin\u20101 and renin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12348","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T09:13:31Z","timestamp":1389604411000},"page":"426-432","source":"Crossref","is-referenced-by-count":23,"title":["The effects of dexmedetomidine on early stage renal functions in pediatric patients undergoing cardiac angiography using non\u2010ionic contrast media: a double\u2010blind, randomized clinical 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