{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T10:05:12Z","timestamp":1783764312048,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postoperative nausea and vomiting (<jats:styled-content style=\"fixed-case\">PONV<\/jats:styled-content>) is a common complication after pediatric strabismus surgery. Steroids and ondansetron (a 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>3<\/jats:sub> antagonist) can effectively reduce nausea, vomiting, and pain and thus might be useful agents for the prevention of <jats:styled-content style=\"fixed-case\">PONV<\/jats:styled-content> in pediatric patients. The aim of this study was to conduct a systematic review and meta\u2010analysis of randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) to evaluate the prophylactic effects of dexamethasone and ondansetron on <jats:styled-content style=\"fixed-case\">PONV<\/jats:styled-content> after strabismus surgery in pediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was conducted to identify <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s that investigated the efficacy and safety of intravenous dexamethasone or ondansetron on <jats:styled-content style=\"fixed-case\">PONV<\/jats:styled-content> in pediatric strabismus surgical patients. The primary outcome was the incidence of <jats:styled-content style=\"fixed-case\">PONV<\/jats:styled-content> during the initial 24 postoperative hours. The secondary outcomes were number of patients requiring a rescue antiemetic and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 13 <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s that evaluated 2006 patients. In the two studies that compared dexamethasone and placebo treatments, <jats:styled-content style=\"fixed-case\">POV<\/jats:styled-content> occurred in 34.3% (23\/67) of the patients in the dexamethasone group and in 68.2% (45\/66) of the patients in the placebo group. The difference between the two groups was significant (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.50; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0.34\u20130.72). Similarly, seven studies that compared ondansetron and a placebo identified a relatively lower incidence of <jats:styled-content style=\"fixed-case\">PONV<\/jats:styled-content> in the ondansetron group (103\/277, 37.2%) than in the placebo group (177\/270, 65.6%). The difference between the two groups was also significant (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.58; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.43\u20130.79). The combination of dexamethasone and ondansetron was significantly more effective at reducing the incidence of <jats:styled-content style=\"fixed-case\">POV<\/jats:styled-content> than dexamethasone or ondansetron alone. In all included <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s, experimental drug\u2010related complications, such as facial flushing and headache, were limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Surgeons and anesthesiologists are recommended to administer the combination of dexamethasone and ondansetron to pediatric patients undergoing strabismus surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12374","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T13:19:28Z","timestamp":1394457568000},"page":"490-498","source":"Crossref","is-referenced-by-count":61,"title":["Dexamethasone, ondansetron, and their combination and postoperative nausea and vomiting in children undergoing strabismus surgery: a meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"24","author":[{"given":"Yun\u2010Dun","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Taipei Medical University\u2010Shuang Ho Hospital New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Taipei Medical University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Humanities in Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Hsiung","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of General Surgery Department of Surgery Taipei Medical, University\u2010Shuang Ho Hospital New Taipei City Taiwan"},{"name":"Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih\u2010Giun","family":"Cherng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Department of Anesthesiology Taipei Medical University\u2010Shuang Ho Hospital New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka\u2010Wai","family":"Tam","sequence":"additional","affiliation":[{"name":"Division of General Surgery Department of Surgery Taipei Medical, University\u2010Shuang Ho Hospital New Taipei City Taiwan"},{"name":"Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Center for Evidence\u2010Based Medicine Taipei Medical University Taipei Taiwan"},{"name":"Center for Evidence\u2010Based Health Care Taipei Medical University\u2010Shuang Ho Hospital New Taipei City 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