{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:05:38Z","timestamp":1696482338822},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Wiedeking Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Artificial colloids, frequently used to prevent hemorrhagic shock in children, may induce serious renal side effects in critically ill adult patients. The impact of perioperative colloid infusion on the renal function in adults and children remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the impact of single doses of artificial colloids on renal function tests, we conducted an experimental animal study. We hypothesized that neither the infusion of moderate doses of 6% hydroxyethyl starch (<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>) nor of 4% gelatin (<jats:styled-content style=\"fixed-case\">GEL<\/jats:styled-content>) would have a serious impact on the renal function of healthy piglets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen sedated piglets were randomly assigned to receive an infusion of either 20\u00a0ml\u00b7kg<jats:sup>\u22121<\/jats:sup> <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">GEL<\/jats:styled-content> or a balanced electrolyte solution (<jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content>, control group) over 30\u00a0min. Before and 7\u00a0days after infusion, serum and urine renal function tests were recorded and renal biopsies were taken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum and urine renal function tests (e.g., creatinine, urea, cystatin C, and neutrophil gelatinase\u2010associated lipocalin) were within normal ranges, and a microscopic examination of the renal tissue in all groups revealed no major alterations such as tubular necrosis, interstitial bleeding, interstitial inflammation, or vacuoles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this pediatric animal model, the infusion of moderate doses of artificial colloids was not found to have any relevant impact on renal function. Further clinical investigations are necessary to provide a conclusive assessment of the risk for renal impairment after <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GEL<\/jats:styled-content> administration during major pediatric surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12445","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T12:34:48Z","timestamp":1402403688000},"page":"974-979","source":"Crossref","is-referenced-by-count":9,"title":["Impact of 6% hydroxyethyl starch 130\/0.42 and 4% gelatin on renal function in a pediatric animal model"],"prefix":"10.1111","volume":"24","author":[{"given":"Lars","family":"Witt","sequence":"first","affiliation":[{"name":"Clinic of Anaesthesiology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Glage","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Science and Experimental Pathology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Schulz","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Science and Experimental Pathology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Lichtinghagen","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Simann","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Intensive Care Clinical Center Oststadt\u2010Heidehaus Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"S\u00fcmpelmann","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesiology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328339384e"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070716"},{"key":"e_1_2_7_4_1","first-page":"CD007594","article-title":"Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function","volume":"7","author":"Mutter TC","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204242"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209759"},{"key":"e_1_2_7_7_1","unstructured":"PRAC recommends suspending marketing authorisations for infusion solutions containing hydroxyethyl\u2010starch. Available at:http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Referrals_document\/Solutions_for_infusion_containing_hydroxyethyl_starch\/Recommendation_provided_by_Pharmacovigilance_Risk_Assessment_Committee\/WC500144448.pdf. Accessed 20 December 2013."},{"key":"e_1_2_7_8_1","unstructured":"Hydroxyethyl\u2010starch solutions (HES) should no longer be used in patients with sepsis or burn injuries or in critically ill patients\u2013CMDh endorses PRAC recommendation. Available at:http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Press_release\/2013\/10\/WC500153125.pdf. 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