{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:30:39Z","timestamp":1774085439343,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T00:00:00Z","timestamp":1403913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant Hyperthermia (<jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content>) is a potentially fatal metabolic disorder. Due to its rarity, limited evidence exists about risk factors, morbidity, and mortality especially in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Nationwide Inpatient Sample and the Kid's Inpatient Database (<jats:styled-content style=\"fixed-case\">KID<\/jats:styled-content>), admissions with the <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u20109 code for <jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content> (995.86) were extracted for patients 0\u201317\u00a0years of age. Demographic characteristics were analyzed. Logistic regression was performed to identify patient and hospital characteristics associated with mortality. A subset of patients with a surgical <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u20109 code in the <jats:styled-content style=\"fixed-case\">KID<\/jats:styled-content> was studied to calculate the prevalence of <jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content> in the dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 310 pediatric admissions were seen in 13 nonoverlapping years of data. Patients had a mortality of 2.9%. Male sex was predominant (64.8%), and 40.5% of the admissions were treated at centers not identified as children's hospitals. The most common associated diagnosis was rhabdomyolysis, which was present in 26 cases. Regression with the outcome of mortality did not yield significant differences between demographic factors, age, sex race, or hospital type, pediatric vs nonpediatric. Within a surgical subset of 530\u00a0449 admissions, <jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content> was coded in 55, giving a rate of 1.04 cases per 10\u00a0000 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study is the first to combine two large databases to study <jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content> in the pediatric population. The analysis provides an insight into the risk factors, comorbidities, mortality, and prevalence of <jats:styled-content style=\"fixed-case\">MH<\/jats:styled-content> in the United States population. Until more methodologically rigorous, large\u2010scale studies are done, the use of databases will continue to be the optimal method to study rare diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12466","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T06:31:22Z","timestamp":1403937082000},"page":"1212-1216","source":"Crossref","is-referenced-by-count":26,"title":["Pediatric malignant hyperthermia: risk factors, morbidity, and mortality identified from the Nationwide Inpatient Sample and Kids' Inpatient Database"],"prefix":"10.1111","volume":"24","author":[{"given":"Jose H.","family":"Salazar","sequence":"first","affiliation":[{"name":"Department of Surgery Johns Hopkins School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Health, Behavior &amp; Society Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia &amp; Critical Care Medicine Johns Hopkins School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fizan","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae W.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Minnesota University of Minnesota Children's Hospital Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,28]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"GeneReviews(R)","author":"Rosenberg H","year":"1993"},{"key":"e_1_2_8_3_1","unstructured":"Causative RYR1 mutations: European Malignant Hyperthermia Group;2014. Available at:http:\/\/emhg.org\/genetics\/mutations-in-ryr1\/. Accessed: 20 May 2014."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2011.03649.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c6b9b2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0867"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318190bb08"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181ac1548"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181adf739"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.12466","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.12466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:32:10Z","timestamp":1696246330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.12466"}},"subtitle":[],"editor":[{"given":"Barbara","family":"Brandom","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,28]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/pan.12466"],"URL":"https:\/\/doi.org\/10.1111\/pan.12466","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,28]]}}}