{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:11:40Z","timestamp":1695618700485},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Optimizing systemic oxygen delivery (<jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content><jats:sub>2<\/jats:sub>) and hemodynamics in children with hypoplastic left heart syndrome (<jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content>) is a clinical challenge. Mathematical modeling of the <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content> circulation has been used to determine the relationship between oxygen kinetic parameters and <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content><jats:sub>2<\/jats:sub> and to determine how <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content><jats:sub>2<\/jats:sub> might be optimized. The model demonstrates that neither arterial oxygen saturation (SaO<jats:sub>2<\/jats:sub>) nor mixed venous oxygen saturation (SvO<jats:sub>2<\/jats:sub>) alone accurately predicts <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content><jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oxygen delivery kinetics predicted by previously described mathematical modeling were compared with actual patients' hemodynamic data. We sought to determine which patient derived parameters correlated best with <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content><jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">HLHS<\/jats:styled-content> who underwent cardiac catheterization prior to surgery to create a superior cavopulmonary anastomosis from 2007 to 2011 were identified. Hemodynamic data obtained were compared with the data derived from the mathematical model. Correlations between SaO<jats:sub>2<\/jats:sub>, SvO<jats:sub>2<\/jats:sub>, SaO<jats:sub>2<\/jats:sub>\u2010SvO<jats:sub>2<\/jats:sub>, SaO<jats:sub>2<\/jats:sub>\/(SaO<jats:sub>2<\/jats:sub>\u2010SvO<jats:sub>2<\/jats:sub>), pulmonary\u2010to\u2010systemic blood flow ratio (<jats:italic>Q<\/jats:italic><jats:sub>p<\/jats:sub>\/<jats:italic>Q<\/jats:italic><jats:sub>s<\/jats:sub>), and <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content><jats:sub>2<\/jats:sub> were evaluated using both linear and nonlinear analyses, and <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results\/Conclusions<\/jats:title><jats:p>Patients' data fit most aspects of the mathematical model. <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content><jats:sub>2<\/jats:sub> had the best correlation with SaO<jats:sub>2<\/jats:sub>\/(SaO<jats:sub>2<\/jats:sub>\u2010SvO<jats:sub>2<\/jats:sub>; <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.8755) followed by SaO<jats:sub>2<\/jats:sub>\u2010SvO<jats:sub>2<\/jats:sub> (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.8063), while SaO<jats:sub>2<\/jats:sub> or SvO<jats:sub>2<\/jats:sub> alone did not demonstrate a significant correlation as predicated by the mathematical model (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.09564 and 0.4831, respectively). SaO<jats:sub>2<\/jats:sub>\/(SaO<jats:sub>2<\/jats:sub>\u2010SvO<jats:sub>2<\/jats:sub>) would be useful clinically to track changes in <jats:styled-content style=\"fixed-case\">DO<\/jats:styled-content><jats:sub>2<\/jats:sub> that occur with changes in patient condition or with interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12517","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T07:31:37Z","timestamp":1409211097000},"page":"174-179","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of actual oxygen delivery kinetics to those predicted by mathematical modeling following stage 1 palliation just prior to superior cavopulmonary anastomosis"],"prefix":"10.1111","volume":"25","author":[{"given":"Koichi","family":"Yuki","sequence":"first","affiliation":[{"name":"Cardiac Anesthesia Division Department of Anesthesiology, Perioperative and Pain Medicine Boston Children's Hospital Boston MA USA"},{"name":"Department of Anaesthesia Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"DiNardo","sequence":"additional","affiliation":[{"name":"Cardiac Anesthesia Division Department of Anesthesiology, Perioperative and Pain Medicine Boston Children's Hospital Boston MA USA"},{"name":"Department of Anaesthesia Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.21.2198"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.14.1407"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1213\/ANE.0b013e31825d36a1","article-title":"A mathematical model of transitional circulation toward biventricular repair in hypoplastic left heart syndrome","volume":"115","author":"Yuki K","year":"2012","journal-title":"Anesth Analg"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2005.12.043"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.22.2699"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs089"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02524795"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000032878.55215.bd"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.05.047"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01772-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01316-3"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.12517","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.12517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:25:52Z","timestamp":1695565552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.12517"}},"subtitle":[],"editor":[{"given":"Greg","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,28]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/pan.12517"],"URL":"https:\/\/doi.org\/10.1111\/pan.12517","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,28]]}}}