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Treatment must be instituted early and is aimed at reversing the airway inflammation, bronchoconstriction, and hyper\u2010reactivity that often lead to lower airway obstruction, impaired ventilation, and oxygenation. Most patients are effectively treated with standard therapy including beta2\u2010adrenergic agonists and corticosteroids. Others necessitate adjunctive therapies and escalation to noninvasive ventilation or intubation. We will review the pathophysiology, evaluation, and treatment options for pediatric patients presenting with status asthmaticus with a particular focus on refractory status asthmaticus treated with volatile anesthetics. In addition, we include a proven approach to the management of these patients in the critical care setting, which requires close coordination between critical care and anesthesia providers. We present a case series of three patients, two of which have the longest reported cases of continuous isoflurane use in status asthmaticus. This series was obtained from a retrospective chart review and highlights the efficacy of the volatile anesthetic, isoflurane, in three pediatric patients with refractory life\u2010threatening status asthmaticus.<\/jats:p>","DOI":"10.1111\/pan.12577","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T11:51:07Z","timestamp":1420717867000},"page":"460-467","source":"Crossref","is-referenced-by-count":45,"title":["Volatile anesthetics for status asthmaticus in pediatric patients: a comprehensive review and case series"],"prefix":"10.1111","volume":"25","author":[{"given":"Sabrina","family":"Carri\u00e9","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Department of Anesthesia Critical Care and Pain Medicine Boston MA USA"},{"name":"McGill University Health Center Department of Anesthesia Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas 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