{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:42:05Z","timestamp":1772628125442,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM108554"],"award-info":[{"award-number":["T32GM108554"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Craniofacial reconstructive surgery for craniosynostosis is associated with large blood loss and intraoperative transfusion. This blood loss may continue through the initial postoperative period, potentially resulting in transfusion postoperatively. The purpose of this study is to determine if there is an association between any modifiable intraoperative factors and postoperative blood transfusion in this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 55 pediatric patients who underwent primary craniofacial reconstruction at Vanderbilt Children's Hospital from January 1, 2013 to April 31, 2014 was analyzed. The authors analyzed 20 different demographic and perioperative variables for statistical associations with postoperative <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content> transfusion using multiple logistic regression with optimal models being selected by Bayesian model averaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The optimal regression model only included initial <jats:styled-content style=\"fixed-case\">PACU<\/jats:styled-content> Hct as a predictor and showed a significant association between this variable and postoperative <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content> transfusion (odds ratio 0.69, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.55\u20130.87, <jats:italic>P\u00a0<\/jats:italic>= 0.0016). Based on the average decrease in postoperative hematocrit (Hct) and the postoperative transfusion trigger, an initial <jats:styled-content style=\"fixed-case\">PACU<\/jats:styled-content> Hct threshold of 30 was calculated. In our patient sample, an initial <jats:styled-content style=\"fixed-case\">PACU<\/jats:styled-content> Hct above 30 was associated with a 50% decrease in the absolute risk of receiving a <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content> transfusion postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on this retrospective analysis, it may be justifiable to transfuse residual volume from previously exposed intraoperative <jats:styled-content style=\"fixed-case\">PRBC<\/jats:styled-content>s to a Hct above 30 to decrease the likelihood of subsequent blood transfusions from different donors in the postoperative period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12600","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T14:16:22Z","timestamp":1418307382000},"page":"294-300","source":"Crossref","is-referenced-by-count":13,"title":["Intraoperative optimization to decrease postoperative <scp>PRBC<\/scp> transfusion in children undergoing craniofacial reconstruction"],"prefix":"10.1111","volume":"25","author":[{"given":"Thanh T.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Pediatric Anesthesiology Department of Anesthesiology Vanderbilt University School of Medicine Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humphrey V.","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Pediatric Anesthesiology Department of Anesthesiology Vanderbilt University School of Medicine Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxie","family":"Phillips","sequence":"additional","affiliation":[{"name":"Lincoln Memorial University DeBusk College of Osteopathic Medicine Harrogate TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clasherrol","family":"Edwards","sequence":"additional","affiliation":[{"name":"Meharry Medical College Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Austin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Anesthesiology Department of Anesthesiology Vanderbilt University School of Medicine Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31819b9429"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318210f9e3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318210fd8f"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12341"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.101"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2010.03464.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.03227.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31825b561b"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005352"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176344136"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1009212519"},{"key":"e_1_2_8_13_1","first-page":"2","article-title":"BMA: 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