{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:27:13Z","timestamp":1782973633879,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CSL Behring AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Results of a previously published study demonstrated a significant decrease in transfusion requirements and calculated blood loss for pediatric major craniosynostosis surgery, if a <jats:styled-content style=\"fixed-case\">ROTEM<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> <jats:styled-content style=\"fixed-case\">FIBTEM<\/jats:styled-content> trigger of &lt;13 mm (early substitution group) was applied as compared to a trigger of &lt;8 mm (conventional group). The aim of this study was a <jats:italic>posthoc<\/jats:italic> analysis of the costs for this coagulation management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The total volume as well as the number of units or bags for all transfused blood products and coagulation factors were recorded for each case. The number of laboratory and point\u2010of\u2010care coagulation tests was also analyzed. Total blood product costs were calculated according to the local prices per unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total cost for all transfused\/administered blood products\/coagulation factors per patient was a median of 1023<jats:styled-content style=\"fixed-case\">EUR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 850<jats:styled-content style=\"fixed-case\">EUR<\/jats:styled-content>\u20131058<jats:styled-content style=\"fixed-case\">EUR<\/jats:styled-content>) in the early substitution group as compared to a median of 910<jats:styled-content style=\"fixed-case\">EUR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 719<jats:styled-content style=\"fixed-case\">EUR<\/jats:styled-content>\u20131351<jats:styled-content style=\"fixed-case\">EUR<\/jats:styled-content>) in the conventional group (<jats:italic>P<\/jats:italic> = 0.81). No difference in the number of coagulation tests performed was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, the use of a higher fibrinogen trigger was not linked to a significant increase in total costs for transfused blood products and coagulation factors, and may offer an economically equivalent approach to coagulation management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12784","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T04:59:14Z","timestamp":1444712354000},"page":"77-83","source":"Crossref","is-referenced-by-count":7,"title":["Economic aspects of intraoperative coagulation management targeting higher fibrinogen concentrations during major craniosynostosis surgery"],"prefix":"10.1111","volume":"26","author":[{"given":"Thorsten","family":"Haas","sequence":"first","affiliation":[{"name":"Department of Anesthesia Zurich University Children's Hospital Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Spielmann","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Zurich University Children's Hospital Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Restin","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Zurich University Hospital Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Zurich University Children's Hospital Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schmugge","sequence":"additional","affiliation":[{"name":"Department of Hematology Zurich University Children's Hospital Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa 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