{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T09:51:14Z","timestamp":1756893074286},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Wiedeking foundation"},{"name":"B.Braun, Melsungen, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Despite serious renal side effects in critically ill adult patients, artificial colloids are still fundamental components of perioperative fluid therapy in infants and children, although the impact of 6% hydroxyethyl starch (<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>) and 4% gelatin (<jats:styled-content style=\"fixed-case\">GEL<\/jats:styled-content>) on renal function during pediatric surgery has not been identified yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the impact of high doses of artificial colloids on renal function, we conducted an experimental animal study and hypothesized that neither the infusion of <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> nor of <jats:styled-content style=\"fixed-case\">GEL<\/jats:styled-content> would have a serious impact on renal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen sedated piglets were randomly assigned to receive an infusion of either 50 ml\u00b7kg<jats:sup>\u22121<\/jats:sup> <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">GEL<\/jats:styled-content>, or a balanced electrolyte solution (crystalloid group). Before and 1 week after infusion, serum and urine renal function tests were recorded and renal biopsies were taken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum and urine renal function tests revealed no increase after administration of <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GEL<\/jats:styled-content>, and only a discrete increase in serum creatinine (median 9.8 \u03bcmol\u00b7l<jats:sup>\u22121<\/jats:sup>, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.0\u201319.1) in the crystalloid group. Histopathological examination indicated a sparsely, multifocal infiltration of mononuclear cells in all groups and an unspecific pyelectasia of one animal in the <jats:styled-content style=\"fixed-case\">GEL<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After high doses of <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">GEL<\/jats:styled-content> in piglets, no relevant impact on renal function could be found. These results confirm that <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">GEL<\/jats:styled-content> is very unlikely in hemodynamically stable perioperative patients with normal renal function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.12834","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T10:00:41Z","timestamp":1451469641000},"page":"259-265","source":"Crossref","is-referenced-by-count":7,"title":["Impact of high doses of 6% hydroxyethyl starch 130\/0.42 and 4% gelatin on renal function in a pediatric animal model"],"prefix":"10.1111","volume":"26","author":[{"given":"Lars","family":"Witt","sequence":"first","affiliation":[{"name":"Clinic of Anaesthesiology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silke","family":"Glage","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Science and Experimental Pathology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Lichtinghagen","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Boethig","sequence":"additional","affiliation":[{"name":"Department for Paediatric Cardiology and Intensive Care Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Dennhardt","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesiology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Heiderich","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesiology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Leffler","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesiology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"S\u00fcmpelmann","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesiology Hanover Medical School Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070716"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209759"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204242"},{"key":"e_1_2_9_5_1","unstructured":"Hydroxyethyl\u2010starch solutions (HES) should no longer be used in patients with sepsis or burn injuries or in critically ill patients\u2013CMDh endorses PRAC recommendation. Available fromhttp:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Press_release\/2013\/10\/WC500153125.pdf. 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