{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:52Z","timestamp":1787015932224,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Summary<\/jats:title>\n \n Background and Aims<\/jats:title>\n \n Several studies report the use of thromboelatography (\n TEG<\/jats:styled-content>\n ) to monitor coagulation in pediatric cardiac surgery. The aim of this study was to compare baseline and intraoperative\n TEG<\/jats:styled-content>\n ,\n TEG<\/jats:styled-content>\n \u2010functional fibrinogen, and standard coagulation assays in children with cyanotic and acyanotic congenital heart disease (\n CHD<\/jats:styled-content>\n ) undergoing cardiac surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This is a prospective observational study of 63 children aged <24\u00a0months undergoing cardiac surgery with cardiopulmonary bypass (\n CPB<\/jats:styled-content>\n ). Exclusion criteria included preoperative anticoagulant therapy and hepatic failure.\n <\/jats:p>\n \n We collected blood at anesthesia induction (T1), at lowest temperature after\n CPB<\/jats:styled-content>\n start (T2), and after heparin neutralization (T3). Coagulation was evaluated by\n TEG<\/jats:styled-content>\n (reaction time [\n R<\/jats:italic>\n ]),\n k<\/jats:italic>\n , alpha\u2010angle, maximum amplitude (\n MA<\/jats:styled-content>\n ),\n MA<\/jats:styled-content>\n \u2010fibrinogen (\n MA<\/jats:styled-content>\n \u2010fib), and by standard coagulation assays (prothrombin time, activated partial thromboplastin time, fibrinogen level, platelet [PLT] count).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixty\u2010three patients were enrolled (38 cyanotic and 25 acyanotic). Median age was 4 [\n IQR<\/jats:styled-content>\n 2\u20136]\u00a0months and median weight was 5 [\n IQR<\/jats:styled-content>\n 3.7\u20136.5]\u00a0kg. Most common surgeries were: ventricular septal defect repair (\n n<\/jats:italic>\n \u00a0=\u00a013), Fallot correction (\n n<\/jats:italic>\n \u00a0=\u00a011), and arterial switch operation (\n n<\/jats:italic>\n \u00a0=\u00a010). Cyanotic and acyanotic children were well matched:\n R<\/jats:italic>\n ,\n k<\/jats:italic>\n ,\n MA<\/jats:styled-content>\n , and\n MA<\/jats:styled-content>\n \u2010fib at T1, T2, and T3 were not significantly different between cyanotic and acyanotic children. At T2, significant correlations were showed between\n MA<\/jats:styled-content>\n and PLT count (\n r<\/jats:italic>\n \u00a0=\u00a00.4;\n P<\/jats:italic>\n \u00a0=\u00a00.0008) and\n k<\/jats:italic>\n and plasma fibrinogen level (\n r<\/jats:italic>\n \u00a0=\u00a0\u22120.54;\n P<\/jats:italic>\n \u00a0<\u00a00.0001). At T3, significant correlations were showed between\n MA<\/jats:styled-content>\n and PLT count (\n r<\/jats:italic>\n \u00a0=\u00a00.5;\n P<\/jats:italic>\n \u00a0<\u00a00.0001), G and PLT count (\n r<\/jats:italic>\n \u00a0=\u00a00.6;\n P<\/jats:italic>\n \u00a0<\u00a00.0001), and\n MA<\/jats:styled-content>\n \u2010fib and plasma fibrinogen level (\n r<\/jats:italic>\n \u00a0=\u00a00.5;\n P<\/jats:italic>\n \u00a0=\u00a00.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n According to our findings, cyanosis does not affect\n TEG<\/jats:styled-content>\n parameters in children with\n CHD<\/jats:styled-content>\n . PLT count and plasma fibrinogen significantly correlated (are significantly associated) with\n MA<\/jats:styled-content>\n and\n MA<\/jats:styled-content>\n \u2010fib respectively, suggesting that use of\n TEG<\/jats:styled-content>\n after protamine administration may be prompted for improved hemostatic monitoring in the perioperative phase.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pan.13038","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T09:20:32Z","timestamp":1481275232000},"page":"170-180","source":"Crossref","is-referenced-by-count":22,"title":["Kaolin\u2010activated thromboelastography and standard coagulation assays in cyanotic and acyanotic infants undergoing complex cardiac surgery: a prospective cohort study"],"prefix":"10.1111","volume":"27","author":[{"given":"Alessandra","family":"Rizza","sequence":"first","affiliation":[{"name":"Pediatric Cardiac Anesthesia\/Intensive Care Unit Department of Pediatric Cardiology and Cardiac Surgery Bambino Ges\u00f9 Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaccaria","family":"Ricci","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Anesthesia\/Intensive Care Unit Department of Pediatric Cardiology and Cardiac Surgery Bambino Ges\u00f9 Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pezzella","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Unit Piemonte ASL TO3\u2010Susa Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Favia","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Anesthesia\/Intensive Care Unit Department of Pediatric Cardiology and Cardiac Surgery Bambino Ges\u00f9 Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovina","family":"Di Felice","sequence":"additional","affiliation":[{"name":"Department of Laboratory Bambino Ges\u00f9 Children's Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ranucci","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic\u2010Vascular Anaesthesia and Intensive Care Unit IRCCS Policlinico San Donato Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cogo","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Department of Experimental and Clinical Medicine University of Udine Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2013.54.3.752"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135112447540"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1213\/ANE.0b013e3181cd6d20","article-title":"The relationship among thromboelastography, hemostatic variables and bleeding after cardiopulmonary bypass surgery in children","volume":"110","author":"Moganasundram S","year":"2010","journal-title":"Anesth Analg"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134811.27812.F0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000287645.26763.be"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000085635.68556.22"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00914.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1309\/LABNMY41RUD099J2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.06.019"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/86.4.575"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23923"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer342"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq258"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.11.008"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02752.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.03110.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000043"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1554998"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181e13470"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12109"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-9-32"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199712000-00003"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000531"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.13038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:23:39Z","timestamp":1696191819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.13038"}},"subtitle":[],"editor":[{"given":"Chandra","family":"Ramamoorthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,9]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/pan.13038"],"URL":"https:\/\/doi.org\/10.1111\/pan.13038","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,9]]}}}